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Generic name: meropenem and vaborbactamMER-oh-PEN-em-and-VA-bor-BAK-tam ]
Drug class: Carbapenems / beta-lactamase inhibitors

Medically reviewed by on Nov 20, 2023. Written by Cerner Multum.

What is Vabomere?

Vabomere are antibiotics that fight bacteria.

Vabomere is a combination medicine used to treat serious urinary tract infections in adults.

Vabomere may also be used for purposes not listed in this medication guide.

Vabomere side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Vabomere may cause serious side effects. Call your doctor at once if you have:

Common side effects of Vabomere may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Before you receive Vabomere, tell your doctor if you have a history of allergies to any antibiotic medications.

Before taking this medicine

You may not be able to use this medicine if you have ever had an allergic reaction to any antibiotics, including:

To make sure Vabomere is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Meropenem and vaborbactam can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

How is Vabomere given?

Follow all directions on your prescription label. Do not use Vabomere in larger or smaller amounts or for longer than recommended.

Vabomere is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Vabomere is usually given every 8 to 12 hours for up to 14 days. This medicine must be given slowly, and the infusion can take about 3 hours to complete.

Vabomere is a powder medicine that must be mixed with a liquid (diluent), and then further diluted before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

The diluted mixture must be used within 4 hours if you keep it at room temperature. If you store the IV bag in a refrigerator, use it within 22 hours. Do not freeze.

Each single-use vial (bottle) of meropenem and vaborbactam powder is for one use only. Throw it away after one use, even if there is still medicine left inside.

Do not mix other injectable medications in the same IV bag or tubing used to given your Vabomere injection.

Throw away any unused medicine left in the IV bag after your infusion. Do not not save it for later use.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Vabomere will not treat a viral infection such as the common cold or flu.

Your kidney function may need to be checked while you are using this medicine.

Store unmixed powder at room temperature away from moisture and heat.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Vabomere?

Vabomere can cause confusion, headaches, or other side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What other drugs will affect Vabomere?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with meropenem and vaborbactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.