Trospium / Xanomeline Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.
Applies to trospium / xanomeline: oral capsules.
Side effects include:
Most common adverse reactions (≥5%): nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, GI reflux disease.
For healthcare professionals
Applies to trospium/xanomeline: oral capsule.
General adverse events
The most common adverse reactions were nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, and gastroesophageal reflux disease.[Ref]
Cardiovascular
- Very common (10% or more): Hypertension (11%)
- Common (1% to 10%): Tachycardia/increased heart rate, orthostatic hypotension
- Postmarketing reports: Chest pain, hypertensive crisis, palpitations, supraventricular tachycardia, syncope
Dermatologic
- Postmarketing reports: Rash, angioedema, Stevens-Johnson syndrome
Gastrointestinal
- Very common (10% or more): Nausea (19%), dyspepsia/esophageal discomfort (18%), constipation (17%), vomiting (15%)
- Common (1% to 10%): Abdominal pain, diarrhea, gastroesophageal reflux disease, dry mouth, salivary hypersecretion
- Postmarketing reports: Gastritis
Genitourinary
- Common (1% to 10%): Urinary retention
Hepatic
- Common (1% to 10%): Elevated liver enzymes
- Frequency not reported: Biliary obstruction
Hypersensitivity
- Postmarketing reports: Anaphylactic reaction (including angioedema of the face, lips, tongue, and/or larynx)
Musculoskeletal
- Postmarketing reports: Rhabdomyolysis
Nervous system
- Common (1% to 10%): Dizziness, somnolence, extrapyramidal symptoms (non-akathisia)
- Frequency not reported: Anticholinergic central nervous system effects
- Postmarketing reports: Confusion, delirium, dizziness, hallucinations
Ocular
- Common (1% to 10%): Blurred vision
- Postmarketing reports: Abnormal vision
Respiratory
- Common (1% to 10%): Cough/productive cough
See also:
References
1. (2024) "Product Information. Cobenfy (trospium-xanomeline)." Bristol-Myers Squibb
More about trospium / xanomeline
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Further information
Trospium/xanomeline side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
