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Triban Side Effects

Generic name: benzocaine / trimethobenzamide

Note: This document provides detailed information about Triban Side Effects associated with benzocaine / trimethobenzamide. Some dosage forms listed on this page may not apply specifically to the brand name Triban.

Applies to benzocaine/trimethobenzamide: rectal suppository.

Important warnings This medicine can cause some serious health issues

Use caution when driving, operating machinery, or performing other hazardous activities.

Benzocaine and trimethobenzamide may cause dizziness, drowsiness, or blurred vision.

If you experience dizziness, drowsiness, or blurred vision, avoid these activities.

Avoid drinking alcohol, which may increase drowsiness and dizziness while you are taking benzocaine and trimethobenzamide.

Get emergency medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

If you experience any of the following serious side effects, stop taking benzocaine and trimethobenzamide and seek emergency medical attention or contact your doctor immediately:

Stop using this medication and call your doctor at once if you have any of these serious side effects:

Other less serious side effects are more likely to occur. Continue using benzocaine and trimethobenzamide and talk with your doctor if you have any of these less serious side effects:

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For healthcare professionals

Applies to benzocaine / trimethobenzamide: rectal suppository.

Cardiovascular

Cardiovascular side effects have included hypotension. It has been occasionally associated with intramuscular administration of trimethobenzamide in surgical patients.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea.[Ref]

Hematologic

Hematologic side effects have rarely included blood dyscrasias. Methemoglobinemia, characterized by cyanosis, has been reported with the use of benzocaine topical.[Ref]

Hepatic

Hepatic side effects have included hepatotoxicity and jaundice associated with the use of trimethobenzamide.[Ref]

An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.[Ref]

Hypersensitivity

Hypersensitivity side effects have included allergic-type skin reactions. Bronchospasm, shock, and anaphylactoid reactions may occur and, in general, have occurred with high plasma levels of the local anesthetic. Parkinson-like symptoms have been reported following the use of trimethobenzamide. These have abated following drug discontinuation, but in some cases treatment may be indicated.[Ref]

Musculoskeletal

Musculoskeletal side effects have included muscle cramps associated with the use of trimethobenzamide.[Ref]

Nervous system

Nervous system side effects have included dizziness, drowsiness, headache, disorientation, convulsions, opisthotonus, Parkinson's-like symptoms, trismus, and extrapyramidal symptoms.[Ref]

Extrapyramidal reactions to trimethobenzamide have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.[Ref]

Psychiatric

Psychiatric side effects have included depression.[Ref]

Local

Local side effects have included burning, stinging, tenderness, and sloughing following the use of benzocaine topical. Pain has been reported following the intramuscular administration of trimethobenzamide.[Ref]

Ocular

Ocular side effects have included blurred vision following the use of trimethobenzamide.[Ref]

References

1. (2001) "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc

Further information

Triban side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.