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Trabectedin Side Effects

Medically reviewed by Last updated on May 13, 2023.

Applies to trabectedin: intravenous powder for solution.

Serious side effects of Trabectedin

Along with its needed effects, trabectedin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking trabectedin:

More common

Less common


Incidence not known

Other side effects of Trabectedin

Some side effects of trabectedin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to trabectedin: intravenous powder for injection.


Very common (10% or more): Increased ALT (up to 96.1%), increased AST (up to 89.5%), increased alkaline phosphatase (up to 70%), hyperbilirubinemia (up to 25.2%), increased gamma-glutamyltransferase (% unavailable)

Common (1% to 10%): Drug-induced liver injury

Uncommon (0.1% to 1%): Hepatotoxicity

Frequency not reported: Hepatic failure, increased conjugated bilirubin[Ref]


Very common (10% or more): Anemia (up to 96%), neutropenia (up to 91.6%), leukopenia (up to 94.9%), thrombocytopenia (up to 63.7%)

Common (1% to 10%): Febrile neutropenia, neutropenic sepsis, pancytopenia, bone marrow failure, granulocytopenia

Uncommon (0.1% to 1%): Neutropenic infection[Ref]


Very common (10% or more): Nausea (up to 75%), vomiting (up to 51.7%), constipation (up to 37%), diarrhea (up to 35%), stomatitis (up to 19.2%),

Common (1% to 10%): Abdominal pain, dyspepsia, upper abdominal pain[Ref]


Very common (10% or more): Fatigue/asthenia/malaise (up to 69%), peripheral edema (up to 28%), mucosal inflammation (up to 11.4%), pyrexia (up to 10.2%)

Common (1% to 10%): Infection, edema, injection site reaction

Uncommon (0.1% to 1%): Septic shock

Frequency not reported: Multi-organ failure, catheter site reactions

Postmarketing reports: Extravasation/tissue necrosis[Ref]


Very common (10% or more): Hypoalbuminemia (up to 63%), decreased appetite (up to 37%), anorexia (up to 28.8%)

Common (1% to 10%): Dehydration, hypokalemia, decreased weight[Ref]


Very common (10% or more): Increased creatinine (up to 46%)

Common (1% to 10%): Renal failure[Ref]


Very common (10% or more): Elevated creatine phosphokinase (up to 33%), arthralgia (up to 15%), myalgia (up to 12%)

Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Rhabdomyolysis

Frequency not reported: Musculoskeletal pain[Ref]


Very common (10% or more): Dyspnea (up to 25%)

Common (1% to 10%): Cough, pulmonary embolism

Uncommon (0.1% to 1%): Pulmonary edema[Ref]

Nervous system

Very common (10% or more): Headache (up to 25%)

Common (1% to 10%): Peripheral neuropathy, dysgeusia, dizziness, paresthesia

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Hypoesthesia[Ref]


Very common (10% or more): Palmar-plantar erythrodysesthesia (up to 24%), alopecia (up to 12%)

Common (1% to 10%): Rash, skin hyperpigmentation[Ref]


Very common (10% or more): Insomnia (up to 15%)[Ref]


Common (1% to 10%): Cardiomyopathy, decreased ejection fraction, hypotension, flushing

Uncommon (0.1% to 1%): Left ventricular dysfunction[Ref]


Common (1% to 10%): Hypersensitivity reactions[Ref]


1. Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals. 2010.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.