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Tioconazole 1 Day Side Effects

Generic name: tioconazole topical

Medically reviewed by Last updated on Feb 27, 2021.

Note: This document contains side effect information about tioconazole topical. Some of the dosage forms listed on this page may not apply to the brand name Tioconazole 1 Day.

For the Consumer

Applies to tioconazole topical: intravaginal ointment

Side effects include:

Vulvovaginal burning, irritation, vaginitis, pruritus, headache.

For Healthcare Professionals

Applies to tioconazole topical: vaginal ointment w/applicator


Topical solution:

-Common (1% to 10%): Peripheral edema

-Frequency not reported: Pain[Ref]


Topical solution:

-Uncommon (0.1% to 1%): Rash, dermatitis

-Frequency not reported: Bullous eruption, contact dermatitis, dry skin, nail disorder (including nail discoloration, periungual inflammation, nail pain), pruritus, skin irritation, skin exfoliation, urticaria[Ref]


Topical solution: Local irritation (including local allergic reactions) usually occurred during the first week of therapy and was transient and mild.[Ref]

Topical solution:

-Frequency not reported: Local irritation (including local allergic reactions)

Vaginal ointment:

-Frequency not reported: Burning, itching, pain, irritation, dryness[Ref]


Vaginal ointment:

-Frequency not reported: Increased vaginal burning, increased vaginal itching, increased vaginal irritation, vaginal swelling/redness, difficulty/burning on urination[Ref]


Vaginal ointment:

-Frequency not reported: Abdominal pain/cramping[Ref]


Topical solution:

-Frequency not reported: Allergic reaction

Other formulations than the dermatological preparation:

-Frequency not reported: Anaphylactoid reactions[Ref]

Nervous system

Topical solution:

-Frequency not reported: Paresthesia

Vaginal ointment:

-Frequency not reported: Headache[Ref]


Topical solution:

-Frequency not reported: Periorbital edema[Ref]


Vaginal ointment:

-Frequency not reported: Upper respiratory infection[Ref]

More about Tioconazole 1 Day (tioconazole topical)

Consumer resources

Other brands

Professional resources

Related treatment guides


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Clissold SP, Heel RC "Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses." Drugs 31 (1986): 29-51

3. "Product Information. Vagistat-1 (tioconazole)." Bristol-Myers Squibb, Princeton, NJ.

4. Stein GE, Gurwith D, Mummaw N, Gurwith M "Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis." Antimicrob Agents Chemother 29 (1986): 969-71

5. Onayemi O, Aldridge RD, Shaw S "Allergic contact dermatitis from tioconazole. A report of 2 cases." Contact Dermatitis 26 (1992): 193-4

6. Brunelli D, Vincenzi C, Morelli R, Tosti A "Contact dermatitis from tioconazole." Contact Dermatitis 27 (1992): 120

7. Piletta P, Pasche-Koo F, Saurat JH "Contact dermatitis from tioconazole mimicking "one hand two feet syndrome"." Contact Dermatitis 28 (1993): 308

8. Jones SK, Kennedy CT "Contact dermatitis from tioconazole." Contact Dermatitis 22 (1990): 122-3

9. Faria A, Goncalo S, Goncalo M, Freitas C, Baptista PP "Allergic contact dermatitis from tioconazole." Contact Dermatitis 35 (1996): 250-2

10. Izu R, Aguirre A, Gonzalez M, Diaz-Perez JL "Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles." Contact Dermatitis 26 (1992): 130-1

11. Quirino AP, Barros MA "Contact dermatitis from tioconazole." Contact Dermatitis 30 (1994): 240-1

12. Marren P, Powell S "Contact sensitivity to tioconazole and other imidazoles." Contact Dermatitis 27 (1992): 129-30

13. Gibson G, Buckley A, Murphy GM "Allergic contact dermatitis from tioconazole without cross- sensitivity to other imidazoles." Contact Dermatitis 30 (1994): 308

14. Stubb S, Heikkila H, Reitamo S, Forstrom L "Contact allergy to tioconazole." Contact Dermatitis 26 (1992): 155-8

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.