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Thyrolar-3 Side Effects

Generic name: liotrix

Medically reviewed by Last updated on Feb 5, 2021.

Note: This document contains side effect information about liotrix. Some of the dosage forms listed on this page may not apply to the brand name Thyrolar-3.

For the Consumer

Applies to liotrix: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, liotrix (the active ingredient contained in Thyrolar-3) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking liotrix:

Incidence not determined

  • Chest pain
  • constipation
  • depressed mood
  • difficulty in moving
  • discouragement
  • dryness of the eye
  • dry skin and hair
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fear, nervousness
  • feeling cold
  • feeling sad or empty
  • fever
  • headache
  • hives or welts
  • hoarseness or husky voice
  • increased sweating
  • increased weight
  • increase in blood pressure
  • irritability
  • irritation
  • itching skin
  • joint pain, stiffness or swelling
  • lack of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • muscle aching or cramping
  • muscle pain or stiffness
  • nausea
  • redness of skin
  • shakiness in legs, arms, hands, feet
  • shortness of breath
  • skin rash
  • sleeplessness
  • slowed heartbeat
  • sluggishness
  • swelling of eyelids, face, lips, hands, or feet
  • swollen joints
  • tightness in chest
  • tiredness
  • trembling or shaking of hands or feet
  • trouble concentrating
  • troubled breathing or swallowing
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • weight gain
  • wheezing

Side effects not requiring immediate medical attention

Some side effects of liotrix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined

For Healthcare Professionals

Applies to liotrix: oral tablet


Adverse reactions other than those attributable to hyperthyroidism due to therapeutic overdose are rare. Excessive doses may result in a hypermetabolic state resembling in every respect the condition of endogenous origin.[Ref]


Postmarketing reports: Hypothyroidism, thyroid stimulating hormone (TSH) increased, TSH decreased[Ref]


Postmarketing reports: Palpitation, blood pressure increased, heart rate increased[Ref]


Postmarketing reports: Alopecia, dry skin, urticaria, hyperhidrosis, pruritus[Ref]


Postmarketing reports: Hypersensitivity[Ref]


Postmarketing reports: Arthralgia, myalgia[Ref]


Postmarketing reports: Keratoconjunctivitis sicca[Ref]


Postmarketing reports: Fatigue, sluggishness, weight increased, asthenia, chest pain[Ref]

Nervous system

Postmarketing reports: Headache, tremor[Ref]


Postmarketing reports: Nausea[Ref]


Postmarketing reports: Anxiety, depression, insomnia[Ref]

More about Thyrolar-3 (liotrix)

Consumer resources

Other brands

Professional resources

Related treatment guides


1. "Product Information. Thyrolar (liotrix)." Forest Pharmaceuticals, St. Louis, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.