Teniposide Side Effects
Commonly reported side effects of teniposide include: infection and bone marrow depression. Other side effects include: bronchospasm, hypersensitivity reaction, hypotension, hemorrhage, dyspnea, fever, hypertension, tachycardia, and chills. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to teniposide: intravenous solution
Along with its needed effects, teniposide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking teniposide:More common
- Black, tarry stools
- blood in urine or stools
- cough or hoarseness
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on skin
- shortness of breath
- tightness in chest or wheezing
- troubled breathing
- unusual bleeding or bruising
Check with your doctor as soon as possible if any of the following side effects occur while taking teniposide:More common
- Flushing of face
- sores in mouth or on lips
- unusually fast heartbeat
- unusual tiredness
- Decreased urination
- swelling of face, fingers, feet, or lower legs
- yellow eyes or skin
Some side effects of teniposide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
This medicine often causes a temporary loss of hair. After treatment with teniposide has ended, normal hair growth should return.
For Healthcare Professionals
Applies to teniposide: intravenous solution
Hematologic side effects have included bone marrow suppression which is the most significant toxicity associated with teniposide therapy. Hematologic effects including neutropenia (less than 2,000 ANC/mcL), leukopenia (less than 3,000 WBC/mcL), anemia (88%), thrombocytopenia (less than 100,000 platelets/mcL) (85%), myelosuppression (unspecified) (75%), and bleeding (5%) have been reported. Sepsis, sometimes fatal, may be a consequence of severe myelosuppression.[Ref]
The hypersensitivity reaction may include chills, fever, urticaria, tachycardia, bronchospasm, dyspnea, hypertension or hypotension, and facial flushing. Treatment for a severe hypersensitivity reaction include prompt use of antihistamines, corticosteroids, epinephrine, intravenous fluids, and other supportive measures.
One analysis of hypersensitivity reactions to teniposide concluded that the frequency of the reactions is substantially higher in patients with neuroblastoma and brain tumors.[Ref]
Cardiovascular side effects including hypotension/cardiovascular (2%) have been reported. One episode of sudden death attributable to probable arrhythmia and intractable hypotension has also been reported.[Ref]
Oncologic side effects include one report of a relative risk of developing secondary acute nonlymphocytic leukemia approximately twelve times that of patients treated with less intensive schedules.[Ref]
The patients in the report were children with acute lymphoblastic leukemia in remission who received teniposide plus other chemotherapeutic agents at weekly or twice weekly doses.
Compounds with similar mechanisms of action and mutagenicity profiles have been carcinogenic. Teniposide should be considered to be a potential carcinogen. Teniposide has been shown to be mutagenic in various bacterial and mammalian genetic toxicity tests.[Ref]
Immunologic side effects including infection (12%) have been reported.[Ref]
Dermatologic side effects including alopecia (9%) and rash (3%) have been reported.[Ref]
General side effects including fever and asthenia have been reported.[Ref]
1. "Product Information. Vumon (teniposide)." Bristol-Myers Squibb, Princeton, NJ.
2. Shimizu H, Frankel LS, Culbert SJ "Severe hypertensive reactions to teniposide (VM-26) in infants with congenital leukemia." Am J Pediatr Hematol Oncol 9 (1987): 239-41
3. O'Dwyer PJ, King SA, Fortner CL, Leyland-Jones B "Hypersensitivity reactions to teniposide (VM-26): an analysis." J Clin Oncol 4 (1986): 1262-9
4. McLeod HL, Baker DK Jr, Pui CH, Rodman JH "Somnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemia." Cancer Chemother Pharmacol 29 (1991): 150-4
Some side effects of teniposide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: mitotic inhibitors
Other brands: Vumon
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