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Talicia Side Effects

Generic name: amoxicillin / omeprazole / rifabutin

Medically reviewed by Last updated on Apr 8, 2022.

Note: This document contains side effect information about amoxicillin / omeprazole / rifabutin. Some of the dosage forms listed on this page may not apply to the brand name Talicia.

For the Consumer

Applies to amoxicillin / omeprazole / rifabutin: oral capsule delayed release

Side effects requiring immediate medical attention

Along with its needed effects, amoxicillin/omeprazole/rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / omeprazole / rifabutin:

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, loosening of the skin
  • blood in the urine or stools
  • blurred vision or other change in vision
  • chest pain or tightness
  • chills
  • cloudy urine
  • confusion
  • cough
  • cracks in the skin
  • decreased urine
  • diarrhea
  • difficulty in moving
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • eye pain
  • fast heartbeat
  • fever
  • greatly decreased frequency of urination or amount of urine
  • hives, itching, or skin rash
  • increased thirst
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of heat from the body
  • mood or mental changes
  • muscle aches, cramps, pains, or stiffness
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • scaly skin
  • seizures
  • sensitivity of the eye to light
  • severe stomach cramps and pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach tenderness
  • sweating
  • swelling of the breasts or breast soreness in both females and males
  • swelling of the feet or lower legs
  • tearing
  • trembling
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Side effects not requiring immediate medical attention

Some side effects of amoxicillin / omeprazole / rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • change or loss of taste
  • difficulty having a bowel movement (stool)
  • heartburn
  • indigestion
  • itching of the vagina or genitals
  • loss of appetite
  • stomach discomfort or upset
  • thick, white vaginal discharge with mild or no odor
  • trouble sleeping

Incidence not known

  • Change in taste bad unusual or unpleasant (after) taste
  • continuing ringing or buzzing or other unexplained noise in ears
  • dry skin
  • hair loss or thinning of the hair
  • hearing loss
  • increased sweating

For Healthcare Professionals

Applies to amoxicillin / omeprazole / rifabutin: oral delayed release capsule


The most commonly reported side effects included headache, diarrhea, chromaturia, and rash.[Ref]

Nervous system

Very common (10% or more): Headache (up to 15.6%)

Frequency not reported: Migraine


Postmarketing reports: Convulsions, dizziness


Frequency not reported: Dizziness

Postmarketing reports: Double vision, dream abnormalities, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo


Frequency not reported: Taste perversion[Ref]


Very common (10% or more): Diarrhea (up to 14.3%)

Common (1% to 10%): Abdominal pain, dyspepsia, nausea

Frequency not reported: Abdominal pain lower, abdominal pain upper, Clostridioides difficile-associated diarrhea, epigastric discomfort, oropharyngeal pain, vomiting


Postmarketing reports: Black hairy tongue


Frequency not reported: Acid regurgitation, constipation, flatulence

Postmarketing reports: Abdominal swelling, dry mouth, fatal pancreatitis, fecal discoloration, fundic gland polyps, irritable colon, microscopic colitis, mucosal atrophy of the tongue, pancreatitis, stomatitis


Frequency not reported: Eructation, flatulence[Ref]


Very common (10% or more): Chromaturia (up to 13%)

Common (1% to 10%): Vulvovaginal candidiasis

Frequency not reported: Vaginal discharge, vulvovaginal burning sensation, vulvovaginal mycotic infection, vulvovaginal pruritus


Postmarketing reports: Crystalluria


Postmarketing reports: Glycosuria, hematuria, proteinuria, testicular pain, urinary frequency, urinary tract infection[Ref]


Common (1% to 10%): Rash

Frequency not reported: Maculopapular rash, morbilliform rash, urticaria


Postmarketing reports: Thrombocytopenic purpura


Postmarketing reports: Alopecia, dry skin, hyperhidrosis, petechiae, photosensitivity, pruritus, purpura, urticaria


Frequency not reported: Skin discoloration[Ref]


Frequency not reported: Cutaneous lupus erythematosus, systemic lupus erythematosus


Frequency not reported: Back pain

Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia


Frequency not reported: Arthralgia, myalgia, myositis[Ref]



Postmarketing reports: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia


Postmarketing reports: Agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia


Frequency not reported: Anemia, hemolysis, leukopenia, pancytopenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, lymphopenia[Ref]



Frequency not reported: Asthenia

Postmarketing reports: Tinnitus


Frequency not reported: Asthenia, fever, flu-like syndrome, pain[Ref]


Frequency not reported: Nasal congestion, nasopharyngitis


Frequency not reported: Cough, upper respiratory infection


Frequency not reported: Dyspnea[Ref]



Postmarketing reports: Acute cytolytic hepatitis, cholestasis, cholestatic jaundice, liver dysfunction


Postmarketing reports: Cholestatic disease, fatal liver failure, fatal liver necrosis, hepatocellular disease, jaundice, mixed hepatitis


Frequency not reported: Hepatitis, jaundice[Ref]



Postmarketing reports: Agitation, anxiety, behavioral changes, confusion, hyperactivity, insomnia


Postmarketing reports: Aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness


Frequency not reported: Insomnia[Ref]



Postmarketing reports: Angina, bradycardia, elevated blood pressure, epistaxis, palpitations, peripheral edema, tachycardia


Frequency not reported: Chest pain[Ref]



Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia with/without hypocalcemia and/or hypokalemia, hyponatremia, weight gain


Frequency not reported: Anorexia[Ref]


Frequency not reported: Uveitis


Postmarketing reports: Blurred vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis[Ref]


Frequency not reported: Fungal infection


Postmarketing reports: Microscopic pyuria[Ref]


Frequency not reported: Hypersensitivity reactions[Ref]


Gastroduodenal carcinoids occurred as a manifestation of Zollinger-Ellison syndrome in patients who received long-term treatment; this condition is a manifestation of the underlying condition.[Ref]


Postmarketing reports: Gastroduodenal carcinoids[Ref]



Postmarketing reports: Gynecomastia[Ref]


Frequency not reported: Acute interstitial nephritis


Postmarketing reports: Elevated serum creatinine[Ref]


1. "Product Information. Talicia (amoxicillin / omeprazole / rifabutin)." RedHill Biopharma Inc. (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.