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Talicia Side Effects

Generic name: amoxicillin / omeprazole / rifabutin

Medically reviewed by Drugs.com. Last updated on Nov 18, 2024.

Note: This document provides detailed information about Talicia Side Effects associated with amoxicillin / omeprazole / rifabutin. Some dosage forms listed on this page may not apply specifically to the brand name Talicia.

Applies to amoxicillin / omeprazole / rifabutin: oral capsule delayed release.

Precautions

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, discuss this with your doctor.

Do not use this medicine together with delavirdine (Rescriptor®), rilpivirine ((Edurant®) or products containing rilpivirine (eg, Complera®, Odefsey®), or voriconazole (Vfend®). Using these medicines together may increase risk for more serious side effects.

Using this medicine while you are pregnant can harm your unborn baby. Use birth control pills together with another form of birth control (eg, condom, diaphragm, or contraceptive foam or jelly) to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have chest tightness, rash, itching, fast heartbeat, trouble breathing or swallowing, or large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs while you are using this medicine.

Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. These may be symptoms of serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis (AGEP), toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS).

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you Stop taking amoxicillin / omeprazole / rifabutin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Check with your doctor right away if you have a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after taking this medicine. These could be symptoms of acute tubulointerstitial nephritis.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

Avoid taking this medicine with alcohol.

This medicine may cause your skin, tears, saliva, sweat, urine, or bowel movements to turn a brownish-orange color. Your contact lenses could become permanently discolored.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Common side effects of Talicia

Some side effects of amoxicillin / omeprazole / rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • headache

Less common side effects

  • acid or sour stomach
  • back pain
  • belching
  • change or loss of taste
  • difficulty having a bowel movement (stool)
  • heartburn
  • indigestion
  • itching of the vagina or genitals
  • loss of appetite
  • stomach discomfort or upset
  • thick, white vaginal discharge with mild or no odor
  • trouble sleeping

Incidence not known

  • change in taste bad unusual or unpleasant (after) taste
  • continuing ringing or buzzing or other unexplained noise in ears
  • decreased interest in sexual intercourse
  • dry skin
  • hair loss or thinning of the hair
  • hearing loss
  • inability to have or keep an erection
  • increased sweating
  • loss in sexual ability, desire, drive, or performance

Serious side effects of Talicia

Along with its needed effects, amoxicillin / omeprazole / rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / omeprazole / rifabutin:

Incidence not known

  • black, tarry stools
  • bleeding gums
  • blistering, peeling, loosening of the skin
  • blood in the urine or stools
  • blurred vision or other change in vision
  • chest pain or tightness
  • chills
  • cloudy urine
  • confusion
  • cough
  • cracks in the skin
  • decreased urine
  • diarrhea
  • difficulty in moving
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • eye pain
  • fast heartbeat
  • fever
  • greatly decreased frequency of urination or amount of urine
  • hives, itching, or skin rash
  • increased thirst
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of heat from the body
  • mood or mental changes
  • muscle aches, cramps, pains, or stiffness
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • scaly skin
  • seizures
  • sensitivity of the eye to light
  • severe stomach cramps and pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach tenderness
  • sweating
  • swelling of the breasts or breast soreness in both females and males
  • swelling of the feet or lower legs
  • tearing
  • trembling
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

For healthcare professionals

Applies to amoxicillin / omeprazole / rifabutin: oral delayed release capsule.

General adverse events

The most commonly reported side effects included headache, diarrhea, chromaturia, and rash.[Ref]

Nervous system

Amoxicillin:

Omeprazole:

Rifabutin:

Gastrointestinal

Amoxicillin:

Omeprazole:

Rifabutin:

Genitourinary

Amoxicillin:

Omeprazole:

Dermatologic

Amoxicillin:

Omeprazole:

Rifabutin:

Musculoskeletal

Omeprazole:

Rifabutin:

Hematologic

Amoxicillin:

Omeprazole:

Rifabutin:

Other

Omeprazole:

Rifabutin:

Respiratory

Omeprazole:

Rifabutin:

Hepatic

Amoxicillin:

Omeprazole:

Rifabutin:

Psychiatric

Amoxicillin:

Omeprazole:

Rifabutin:

Cardiovascular

Omeprazole:

Rifabutin:

Metabolic

Omeprazole:

Rifabutin:

Ocular

Omeprazole:

Immunologic

Omeprazole:

Hypersensitivity

Oncologic

Omeprazole:

Gastroduodenal carcinoids occurred as a manifestation of Zollinger-Ellison syndrome in patients who received long-term treatment; this condition is a manifestation of the underlying condition.[Ref]

Endocrine

Omeprazole:

Renal

Omeprazole:

See also:

References

1. (2020) "Product Information. Talicia (amoxicillin / omeprazole / rifabutin)." RedHill Biopharma Inc.

Further information

Talicia side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.