Tagrisso Side Effects

Generic name: osimertinib

Medically reviewed by Drugs.com. Last updated on Sep 11, 2023.

Note: This document contains side effect information about osimertinib. Some dosage forms listed on this page may not apply to the brand name Tagrisso.

Applies to osimertinib: oral tablet.

Serious side effects of Tagrisso

Along with its needed effects, osimertinib (the active ingredient contained in Tagrisso) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking osimertinib:

More common

Anxiety
cough
dizziness, lightheadedness, or fainting
eye or vision changes
fast, pounding, or uneven heartbeat
pain in the chest, groin, or legs, especially the calves
pain, redness, or swelling in the arm or leg
slurred speech
sudden loss of coordination
sudden, severe headache
sudden, severe weakness or numbness in the arm or leg
trouble breathing

Less common

Blurred vision
chills
fever
general feeling of discomfort or illness
inability to speak
seizures
sneezing
sore throat
sudden, severe weakness on one side of the body
temporary blindness
thickening of bronchial secretions

Rare

Chest pain or tightness
eye redness, irritation, or pain
headache
swollen or painful glands
unusual bleeding or bruising

Incidence not known

Blistering, peeling, loosening of the skin
diarrhea
itching
joint or muscle pain
red skin lesions, often with a purple center
sore throat
sores, ulcers, or white spots in the mouth or on the lips
unusual tiredness or weakness

Other side effects of Tagrisso

Some side effects of osimertinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain
changes in the fingernails or toenails, including brittleness, inflammation, pain, redness, tenderness, separation from nail bed, or shedding of the nails
constipation
decreased appetite
nausea
skin rash or dryness of the skin
swelling or inflammation of the mouth

For Healthcare Professionals

Applies to osimertinib: oral tablet.

Hematologic

Very common (10% or more): Lymphopenia (63%), thrombocytopenia (54%), anemia (44%), neutropenia (33%)^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (42%), nausea (17%), decreased appetite (16%), constipation (15%), stomatitis (12%), vomiting (11%)^[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., generalized, erythematous, macular, maculopapular, papular, pustular), erythema, folliculitis, acne, dermatitis, acneiform dermatitis (58%), dry skin (e.g., eczema, skin fissures, xerosis) (36%), nail toxicity (e.g., nail and nail bed disorders, nail bed inflammation, nail bed tenderness, nail discoloration, nail dystrophy, nail infection, nail ridging, onychoclasis, onycholysis, onychomadesis, paronychia) (35%), pruritus (17%)

Postmarketing reports: Erythema Multiforme (EMM), Stevens-Johnson Syndrome (SJS), cutaneous vasculitis^[Ref]

Metabolic

Very common (10% or more): Hyponatremia (26%), hypermagnesemia (20%)^[Ref]

Ocular

Very common (10% or more): Eye disorders (e.g., dry eye, blurred vision, keratitis, cataract, eye irritation, blepharitis, eye pain, increased lacrimation, vitreous floaters) (18%)

Uncommon (0.1% to 1%): Other ocular toxicities^[Ref]