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Sulfanilamide topical Side Effects

For the Consumer

Applies to sulfanilamide topical: vaginal cream

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have severe or worsening vaginal symptoms, such as itching and burning.

Although the risk of serious side effects is low when sulfanilamide is used in the vagina, side effects can occur if the medicine is absorbed into your bloodstream. Call your doctor at once if you have:

  • sudden weakness or ill feeling;

  • fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

  • headache, hunger, weakness, confusion, irritability; or

  • dizziness, sweating, fast heart rate, or feeling jittery.

Common side effects may include:

  • mild burning after inserting the medicine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to sulfanilamide topical: vaginal cream, vaginal suppository


Local side effects associated with sulfanilamide topical cream have included local sensitivity reactions in 0.2% of patients. Local sensitivity reactions (such as increased discomfort or a burning sensation) have occasionally been reported after topical sulfonamide use.[Ref]


1. "Product Information. AVC Cream (sulfanilamide topical)" Aventis Pharmaceuticals, Swiftwater, PA.

It is possible that some side effects of sulfanilamide topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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