Skip to Content

Sulfanilamide topical Pregnancy and Breastfeeding Warnings

Sulfanilamide topical is also known as: AVC

Sulfanilamide topical Pregnancy Warnings

Sulfanilamide topical has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity at high oral doses (7 to 25 times the human therapeutic oral dose), with an increased incidence of cleft palate and other bony abnormalities observed in rats and mice. There are no controlled data in human pregnancy. The safe use of sulfonamides, including sulfanilamide topical, in pregnancy has not been established. Sulfanilamide topical is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Sulfonamides, including sulfanilamide, readily cross the placental barrier and enter fetal circulation. The concentration in the fetus averages from 50% to 90% of that in the maternal blood and if high enough, can cause toxic effects.

See references

Sulfanilamide topical Breastfeeding Warnings

Sulfanilamide topical is excreted into human milk. Absorbed sulfonamides have caused kernicterus in the newborn. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. AVC Cream (sulfanilamide topical)" Aventis Pharmaceuticals, Swiftwater, PA.

References for breastfeeding information

  1. "Product Information. AVC Cream (sulfanilamide topical)" Aventis Pharmaceuticals, Swiftwater, PA.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.