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Streptomycin Side Effects

For the Consumer

Applies to streptomycin: intramuscular powder for solution, intramuscular solution

Along with its needed effects, streptomycin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking streptomycin:

More Common

  • Black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clumsiness
  • cough
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • fever
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • painful or difficult urination
  • sensation of spinning
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unsteadiness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Less Common

  • Back, leg, or stomach pains
  • bleeding gums
  • bloody or cloudy urine
  • blurred vision
  • change in vision
  • dark urine
  • deafness
  • difficulty with breathing
  • difficulty with swallowing
  • dry mouth
  • fast heartbeat
  • general body swelling
  • headache
  • hives
  • impaired vision
  • itching
  • loss of appetite
  • muscle weakness
  • nosebleeds
  • pain in lower back or side
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • thirst
  • tightness in the chest
  • wheezing
  • yellowing of the eyes or skin

Rare

  • Change in the frequency of urination or amount of urine
  • drowsiness
  • increased thirst
  • swelling of the feet or lower legs
  • weakness

Some side effects of streptomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Hives or welts
  • redness of the skin

Less Common

  • Impaired vision

For Healthcare Professionals

Applies to streptomycin: compounding powder, intramuscular powder for injection

Nervous system

Common (1% to 10%): Paresthesia of face, vertigo, vestibular ototoxicity

Frequency not reported: Vestibular dysfunction[Ref]

Vestibular ototoxicity included nausea, vomiting, and vertigo.[Ref]

Dermatologic

Common (1% to 10%): Angioneurotic edema, rash, urticaria

Frequency not reported: Exfoliative dermatitis[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting[Ref]

Hematologic

Common (1% to 10%): Eosinophilia

Frequency not reported: Hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia[Ref]

Renal

Frequency not reported: Azotemia, nephrotoxicity[Ref]

Ocular

Frequency not reported: Amblyopia, hearing impairment[Ref]

Other

Common (1% to 10%): Fever

Frequency not reported: Cochlear ototoxicity, deafness[Ref]

Musculoskeletal

Frequency not reported: Muscular weakness[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

References

1. "Product Information. Streptomycin (streptomycin)." Pfizer US Pharmaceuticals, New York, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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