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Streptomycin Side Effects

Medically reviewed by Last updated on Jan 25, 2024.

Applies to streptomycin: intramuscular powder for solution.


Intramuscular route (Powder for Solution)

The risk of severe neurotoxic reactions is sharply increased in patients with impaired renal function or prerenal azotemia. These include disturbances of vestibular and cochlear function, optic nerve dysfunction, peripheral neuritis, arachnoiditis, and encephalopathy may also occur. The incidence of clinically detectable, irreversible vestibular damage is particularly high in patients treated with streptomycin.Renal function should be monitored carefully; patients with renal impairment and/or nitrogen retention should receive reduced doses. The peak serum concentration in individuals with kidney damage should not exceed 20 to 25 mcg/mL.The concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin and cyclosporine should be avoided.The neurotoxicity of streptomycin can result in respiratory paralysis from neuromuscular blockage, especially when the drug is given soon after the use of anesthesia or muscle relaxants.The administration of streptomycin in parenteral form should be reserved for patients where adequate laboratory and audiometric testing facilities are available during therapy.

Serious side effects of Streptomycin

Along with its needed effects, streptomycin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking streptomycin:

More common

Less common


Other side effects of Streptomycin

Some side effects of streptomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to streptomycin: compounding powder, intramuscular powder for injection.

Nervous system

Common (1% to 10%): Paresthesia of face, vertigo, vestibular ototoxicity

Frequency not reported: Vestibular dysfunction[Ref]

Vestibular ototoxicity included nausea, vomiting, and vertigo.[Ref]


Common (1% to 10%): Angioneurotic edema, rash, urticaria

Frequency not reported: Exfoliative dermatitis[Ref]


Common (1% to 10%): Nausea, vomiting[Ref]


Common (1% to 10%): Eosinophilia

Frequency not reported: Hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia[Ref]


Frequency not reported: Azotemia, nephrotoxicity[Ref]


Frequency not reported: Amblyopia, hearing impairment[Ref]


Common (1% to 10%): Fever

Frequency not reported: Cochlear ototoxicity, deafness[Ref]


Frequency not reported: Muscular weakness[Ref]


Frequency not reported: Anaphylaxis[Ref]


1. Product Information. Streptomycin Sulfate (streptomycin). Pfizer U.S. Pharmaceuticals.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.