Sotyktu Side Effects

Generic name: deucravacitinib

Medically reviewed by Drugs.com. Last updated on Jun 17, 2023.

Note: This document contains side effect information about deucravacitinib. Some dosage forms listed on this page may not apply to the brand name Sotyktu.

Applies to deucravacitinib: oral tablet.

Serious side effects of Sotyktu

Along with its needed effects, deucravacitinib (the active ingredient contained in Sotyktu) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking deucravacitinib:

More common

Body aches or pain
chest tightness
chills
cough
dryness or soreness of the throat
ear congestion
fever
headache
loss of voice
muscle aches
pain or tenderness around eyes and cheekbones
sneezing
sore throat
stuffy or runny nose
swollen glands
trouble breathing
trouble in swallowing
unusual tiredness or weakness
voice changes

Less common

Burning or stinging of skin
painful cold sores or blisters on the lips, nose, eyes, or genitals

Incidence not known

Anxiety
black, tarry stools
chest pain
dizziness or lightheadedness
fainting
general feeling of illness
pain, redness, or swelling in the arm or leg
painful blisters on the trunk of the body
tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
weight loss
yellow skin and eyes

Other side effects of Sotyktu

Some side effects of deucravacitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Blemishes on the skin
burning, itching, and pain in the hairy areas, pus at the root of the hair
irritation or soreness of the mouth
pimples

For Healthcare Professionals

Applies to deucravacitinib: oral tablet.

General

The most common adverse reactions occurring in 1% of patients or greater included upper respiratory infections, increased blood creatine phosphokinase, herpes simplex, mouth ulcers, folliculitis, and acne.^[Ref]

Cardiovascular

Common (1% to 10%): Hypertension^[Ref]

Dermatologic

Common (1% to 10%): Psoriasis, folliculitis, acne, acneiform rash^[Ref]

"Acne" included acne, acne cystic, and dermatitis acneiform.

"Acneiform rash" included acne, dermatitis acneiform, rash, rosacea, pustule, rash pustular, and papule.^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, mouth ulcers^[Ref]

"Mouth ulcers" included aphthous ulcer, tongue ulceration, and stomatitis.^[Ref]

Hepatic

Frequency not reported: Increased liver enzymes (AST, ALT)^[Ref]

Hypersensitivity

Frequency not reported: Angioedema^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, back pain, increased creatine phosphokinase

Frequency not reported: Rhabdomyolysis^[Ref]

Nervous system

Common (1% to 10%): Headache^[Ref]

Oncologic

Uncommon (0.1% to 1%): Malignancies (excluding nonmelanoma skin cancer)^[Ref]

Other

Very common (10% or more): General infections (up to 29%)

Common (1% to 10%): Herpes simplex infections

Uncommon (0.1% to 1%): Herpes zoster, serious infections (including coronavirus disease 2019 [COVID-19], pneumonia)

Frequency not reported: Increased triglycerides, multidermatomal herpes zoster^[Ref]

"Herpes simplex infections" included oral herpes, herpes simplex, genital herpes, and herpes viral infection.^[Ref]

Renal

Frequency not reported: Decreased glomerular filtration rate, worsening proteinuria^[Ref]

Respiratory

Very common (10% or more): Upper respiratory infections (up to 19.2%)^[Ref]

"Upper respiratory infections" includes viral upper respiratory tract infection, pharyngitis, sinusitis, acute sinusitis, rhinitis, tonsillitis, peritonsillar abscess, laryngitis, tracheitis, and rhinotracheitis.^[Ref]