Skip to Content

Sorbitrate Side Effects

Generic Name: isosorbide dinitrate

Note: This page contains side effects data for the generic drug isosorbide dinitrate. It is possible that some of the dosage forms included below may not apply to the brand name Sorbitrate.

For the Consumer

Applies to isosorbide dinitrate: capsule extended release, tablet, tablet chewable, tablet extended release

As well as its needed effects, isosorbide dinitrate (the active ingredient contained in Sorbitrate) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking isosorbide dinitrate, check with your doctor immediately:

  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • difficulty with breathing
  • dizziness or lightheadedness
  • fever
  • headache
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known:
  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast or irregular heartbeat
  • sweating

If any of the following symptoms of overdose occur while taking isosorbide dinitrate, get emergency help immediately:

Symptoms of overdose:
  • Blurred or loss of vision
  • bulging soft spot on the head of an infant
  • change in consciousness
  • change in the ability to see colors, especially blue or yellow
  • cold, clammy skin
  • convulsions
  • disturbed color perception
  • double vision
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • halos around lights
  • headache, severe and throbbing
  • increased sweating
  • loss of appetite
  • loss of consciousness
  • nausea
  • night blindness
  • overbright appearance of lights
  • paralysis
  • sensation of spinning
  • slow heartbeat
  • tunnel vision
  • vomiting

For Healthcare Professionals

Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet


The most common side effect was headache.[Ref]

Nervous system

Frequency not reported: Headache, dizziness, syncope, lightheadedness[Ref]


Common (1% to 10%): Decrease in blood pressure and/or orthostatic hypotension with reflex tachycardia and symptoms/signs of cerebral ischemia (including drowsiness and dizziness and weakness) with first time use and when the dose is increased
Uncommon (0.1% to 1%): Marked decreases in blood pressure with an aggravation of symptomatic angina pectoris, collapse associated with bradycardia and cardiac rhythm disturbances
Frequency not reported: Pallor, crescendo angina, rebound hypertension, hypotension[Ref]


Common (1% to 10%): Peripheral edema in patients treated for left ventricular failure[Ref]


Uncommon (0.1% to 1%): Allergic skin reactions
Very rare (less than 0.01%): Exfoliative dermatitis/Stevens-Johnson Syndrome or angioedema
Frequency not reported: Cutaneous vasodilation with flushing, excessive perspiration, rash[Ref]


Uncommon (0.1% to 1%): Nausea and vomiting
Frequency not reported: Heartburn[Ref]


Very rare (less than 0.01%): Pituitary apoplexy in patients with undiagnosed pituitary tumors[Ref]


Very rare (less than 0.01%): Angle closure glaucoma[Ref]


Very rare (less than 0.01%): Alveolar hypoventilation with consequent hypoxemia and the risk of developing a myocardial infarction in patients with coronary heart disease[Ref]


Frequency not reported: Methemoglobinemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase-deficient syndrome[Ref]


Frequency not reported: Restlessness[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Isordil (isosorbide dinitrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

It is possible that some side effects of Sorbitrate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.