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Sojourn Side Effects

Generic Name: sevoflurane

Note: This document contains side effect information about sevoflurane. Some of the dosage forms listed on this page may not apply to the brand name Sojourn.

For the Consumer

Applies to sevoflurane: inhalation liquid

Along with its needed effects, sevoflurane (the active ingredient contained in Sojourn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. While you are receiving and recovering from an inhalation anesthetic like sevoflurane, your health care professional will closely follow its effects. However, some effects may not be noticed until later.

Some side effects of sevoflurane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

For Healthcare Professionals

Applies to sevoflurane: inhalation liquid

General

The most common adverse events were nausea, vomiting, hypotension, agitation, and cough.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (25%), vomiting (18%)

Common (1% to 10%): Increased salivation

Uncommon (0.1% to 1%): Dry mouth[Ref]

Cardiovascular

Very common (10% or more): Hypotension (11%), bradycardia

Common (1% to 10%): Tachycardia, hypertension

Uncommon (0.1% to 1%): Arrhythmia, ventricular extrasystoles, supraventricular extrasystoles, complete AV block, bigeminy, inverted T wave, atrial fibrillation, atrial arrhythmia, second degree AV block, S-T depressed, extrasystoles

Frequency not reported: QT prolongation, torsade de pointes

Postmarketing reports: Cardiac arrest[Ref]

Respiratory

Very common (10% or more): Cough increased (11%),

Common (1% to 10%): Laryngospasm, airway obstruction, breath holding, apnea, respiratory disorder

Uncommon (0.1% to 1%): Sputum increased, hypoxia, wheezing, bronchospasm, hyperventilation, pharyngitis, hiccup, hypoventilation, dyspnea, stridor, hypoxia, asthma

Postmarketing reports: Pulmonary edema[Ref]

Psychiatric

Very common (10% or more): Agitation (up to 15%)

Uncommon (0.1% to 1%): Crying, nervousness, confusion, insomnia, confusional state[Ref]

Nervous system

Common (1% to 10%): Somnolence, dizziness, movement

Uncommon (0.1% to 1%): Syncope, hypertonia, taste perversion

Postmarketing reports: Seizures, dystonia[Ref]

Other

Common (1% to 10%): Shivering, fever, hypothermia, headache, blood fluoride increased

Uncommon (0.1% to 1%): Asthenia, pain, fluorosis,

Rare (less than 0.1%): Malignant hyperthermia[Ref]

Hematologic

Common (1% to 10%): White blood cell count abnormal

Uncommon (0.1% to 1%): Hemorrhage, leukocytosis, thrombocytopenia, leukopenia

Postmarketing reports: Transient elevations in white blood cell count[Ref]

Hepatic

Common (1% to 10%): Liver function test abnormal

Uncommon (0.1% to 1%): Increases in AST, increases in ALT, bilirubinemia

Postmarketing reports: Hepatic dysfunction, hepatitis, jaundice, hepatic necrosis, hepatic failure, transient elevations in liver function tests[Ref]

Metabolic

Common (1% to 10%): Blood glucose abnormal

Uncommon (0.1% to 1%): Increases in LDH, increases in alkaline phosphatase, hypophosphatemia, acidosis, hyperglycemia

Postmarketing reports: Transient elevations in glucose[Ref]

Renal

Uncommon (0.1% to 1%): Increases in BUN, increases in creatinine, glycosuria, albuminuria,

Frequency not reported: Mild impairment of renal concentrating ability

Postmarketing reports: Acute renal failure[Ref]

Ocular

Uncommon (0.1% to 1%): Amblyopia, conjunctivitis[Ref]

Genitourinary

Uncommon (0.1% to 1%): Urination impaired, urine abnormality, urinary retention, oliguria[Ref]

Dermatologic

Uncommon (0.1% to 1%): Pruritus, rash[Ref]

Hypersensitivity

Postmarketing reports: Allergic reactions, urticaria, bronchospasm, anaphylactic or anaphylactoid reaction, hypersensitivity (including contact dermatitis, rash, dyspnea, wheezing, chest discomfort, swelling face, or anaphylactic reaction)[Ref]

Musculoskeletal

Postmarketing reports: Muscle twitching[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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