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Sojourn Inhalant Dosage

Medically reviewed by Drugs.com. Last updated on Dec 8, 2020.

Generic name: SEVOFLURANE 1mL in 1mL
Dosage form: inhalation anesthetic

The concentration of sevoflurane being delivered from a vaporizer during anesthesia should be known. This may be accomplished by using a vaporizer calibrated specifically for sevoflurane. The administration of general anesthesia must be individualized based on the patient's response.


Replacement of Desiccated CO 2 Absorbents :

When a clinician suspects that the CO 2 absorbent may be desiccated, it should be replaced. The exothermic reaction that occurs with sevoflurane and CO 2 absorbents is increased when the CO 2 absorbents become desiccated, such as after an extended period of dry gas flow through the CO 2 absorbent canisters (see PRECAUTIONS).


Pre-anesthetic Medication:

No specific pre-medication is either indicated or contraindicated with sevoflurane. The decision as to whether or not to premedicate and the choice of pre-medication is left to the discretion of the anesthesiologist.


Induction:

Sevoflurane has a non-pungent odor and does not cause respiratory irritability; it is suitable for mask induction in pediatrics and adults.


Maintenance:

Surgical levels of anesthesia can usually be achieved with concentrations of 0.5 - 3 % sevoflurane with or without the concomitant use of nitrous oxide. Sevoflurane can be administered with any type of anesthesia circuit.


Table 9: MAC Values for Adults and Pediatric Patients According to Age



Age of Patient (years)
Sevoflurane in Oxygen
Sevoflurane in 65% N 2O/35% O 2

0 - 1 months #

3.3%


1 - < 6 months

3.0%


6 months - < 3 years

2.8%

2.0%@

3 - 12

2.5%


25

2.6%

1.4%

40

2.1%

1.1%

60

1.7%

0.9%

80

1.4%

0.7%
# Neonates are full-term gestational age. MAC in premature infants has not been determined.
@ In 1 - < 3 year old pediatric patients, 60% N 2O/40% O 2 was used.



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