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Sojourn Inhalant Dosage

Medically reviewed by Drugs.com. Last updated on Apr 13, 2022.

Generic name: SEVOFLURANE 1mL in 1mL
Dosage form: inhalation anesthetic

The concentration of sevoflurane being delivered from a vaporizer should be known. This may be accomplished by using a vaporizer calibrated specifically for sevoflurane. The administration of general anesthesia must be individualized based on the patient's response.

Replacement of Desiccated CO 2 Absorbents

When a clinician suspects that the CO 2 absorbent may be desiccated, it should be replaced. The exothermic reaction that occurs with sevoflurane and CO 2 absorbents is increased when the CO 2 absorbent becomes desiccated, such as after an extended period of dry gas flow through the CO 2 absorbent canisters (see PRECAUTIONS).

Pre-anesthetic Medication

No specific premedication is either indicated or contraindicated with sevoflurane. The decision as to whether or not to premedicate and the choice of premedication is left to the discretion of the anesthesiologist.

Induction

Sevoflurane has a nonpungent odor and does not cause respiratory irritability; it is suitable for mask induction in pediatrics and adults.

Maintenance

Surgical levels of anesthesia can usually be achieved with concentrations of 0.5 - 3% sevoflurane with or without the concomitant use of nitrous oxide. Sevoflurane can be administered with any type of anesthesia circuit.

Table 9. MAC Values for Adults and Pediatric Patients According to Age

Age of Patient (years)

Sevoflurane in Oxygen

Sevoflurane in 65% N 2O/35% O 2

0 - 1 months #

3.3%

1 - < 6 months

3.0%

6 months - < 3 years

2.8%

2.0%@

3 - 12

2.5%

25

2.6%

1.4%

40

2.1%

1.1%

60

1.7%

0.9%

80

1.4%

0.7%

# Neonates are full-term gestational age. MAC in premature infants has not been determined.

@ In 1 - < 3 year old pediatric patients, 60% N 2O/40% O 2 was used.

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