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Simbrinza Side Effects

Generic name: brimonidine / brinzolamide ophthalmic

Medically reviewed by Last updated on Jan 30, 2024.

Note: This document contains side effect information about brimonidine / brinzolamide ophthalmic. Some dosage forms listed on this page may not apply to the brand name Simbrinza.

Applies to brimonidine/brinzolamide ophthalmic: ophthalmic suspension.

Serious side effects of Simbrinza

Along with its needed effects, brimonidine/brinzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine / brinzolamide ophthalmic:

More common

Less common


Incidence not known

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking brimonidine / brinzolamide ophthalmic:

Symptoms of overdose

Other side effects of Simbrinza

Some side effects of brimonidine / brinzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to brimonidine / brinzolamide ophthalmic: ophthalmic suspension.


Uncommon (0.1% to 1%): Cardio-respiratory distress, angina pectoris, arrhythmia, palpitations, irregular heart rate, bradycardia, tachycardia, hypotension, chest discomfort

Very rare (less than 0.01%): Hypertension

Frequency not reported: Chest pain

Postmarketing reports: Pallor[Ref]


Uncommon (0.1% to 1%): Contact dermatitis, urticaria, rash, maculo-papular rash, generalized pruritus, alopecia, skin tightness

Frequency not reported: Dermatitis, erythema[Ref]


Common (1% to 10%): Dry mouth

Uncommon (0.1% to 1%): Dyspepsia, esophagitis, abdominal discomfort, diarrhea, vomiting, nausea, frequent bowel movements, flatulence, oral hypoesthesia, oral paresthesia[Ref]


The most commonly reported side effects were blurred vision, ocular hyperemia, eye allergy, dry mouth, and dysgeusia.[Ref]


Uncommon (0.1% to 1%): Hypersensitivity[Ref]


Uncommon (0.1% to 1%): Back pain, muscle spasms, myalgia

Frequency not reported: Arthralgia, pain in extremity[Ref]

Nervous system

Common (1% to 10%): Somnolence, dizziness, dysgeusia

Uncommon (0.1% to 1%): Headache, motor dysfunction, amnesia, memory impairment, paresthesia, vertigo, tinnitus, feeling jittery

Very rare (less than 0.01%): Syncope

Frequency not reported: Tremor, hypoesthesia, ageusia

Postmarketing reports: Coma, lethargy[Ref]


Common (1% to 10%): Eye allergy, keratitis, eye pain, ocular discomfort, blurred vision, abnormal vision, ocular hyperemia, conjunctival blanching

Uncommon (0.1% to 1%): Corneal erosion, corneal edema, blepharitis, corneal deposits (keratic precipitates), conjunctival disorder (papilla) , photophobia, photopsia, eye swelling, eyelid edema, conjunctival edema, dry eye, eye discharge, reduced visual acuity, increased lacrimation, pterygium, erythema of eyelid, meibomianitis, diplopia, glare, eye hypoesthesia, scleral pigmentation, subconjunctival cyst, abnormal sensation in eye, asthenopia

Very rare (less than 0.01%): Uveitis, miosis

Frequency not reported: Visual disturbances, madarosis

Postmarketing reports: Iritis, keratoconjunctivitis sicca[Ref]


Uncommon (0.1% to 1%): Pain, feeling abnormal, irritability

Frequency not reported: Face edema, peripheral edema

Postmarketing reports: Hypothermia[Ref]


Uncommon (0.1% to 1%): Apathy, depression, insomnia, nightmare, nervousness[Ref]


Uncommon (0.1% to 1%): Renal pain

Frequency not reported: Pollakiuria[Ref]


Uncommon (0.1% to 1%): Nasopharyngitis, pharyngitis, sinusitis, dyspnea, bronchial hyperactivity, pharyngolaryngeal pain, dry throat, cough, epistaxis, upper respiratory tract congestion, nasal congestion, rhinorrhea, throat irritation, nasal dryness, postnasal drip, sneezing

Frequency not reported: Rhinitis, asthma

Postmarketing reports: Apnea, respiratory depression[Ref]


Uncommon (0.1% to 1%): Decreased libido, erectile dysfunction[Ref]


Uncommon (0.1% to 1%): Decreased red blood cell, increased blood chloride[Ref]


Frequency not reported: Abnormal liver function[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Simbrinza (brimonidine-brinzolamide ophthalmic). Alcon Laboratories Inc. 2013.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.