Simbrinza Side Effects

Generic name: brimonidine / brinzolamide ophthalmic

Medically reviewed by Drugs.com. Last updated on Jan 15, 2025.

Note: This document provides detailed information about Simbrinza Side Effects associated with brimonidine / brinzolamide ophthalmic. Some dosage forms listed on this page may not apply specifically to the brand name Simbrinza.

Applies to brimonidine/brinzolamide ophthalmic: ophthalmic suspension.

Serious side effects of Simbrinza

Along with its needed effects, brimonidine/brinzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine / brinzolamide ophthalmic:

Get emergency help immediately if any of the following symptoms of overdose occur while taking brimonidine / brinzolamide ophthalmic:

Symptoms of overdose

• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• seizures
• sweating
• trembling
• weakness and heaviness of the legs

Other side effects of Simbrinza

Some side effects of brimonidine / brinzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to brimonidine / brinzolamide ophthalmic: ophthalmic suspension.

General adverse events

The most commonly reported side effects were blurred vision, ocular hyperemia, eye allergy, dry mouth, and dysgeusia.^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Contact dermatitis, urticaria, rash, maculo-papular rash, generalized pruritus, alopecia, skin tightness
• Frequency not reported: Dermatitis, erythema^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth
• Uncommon (0.1% to 1%): Dyspepsia, esophagitis, abdominal discomfort, diarrhea, vomiting, nausea, frequent bowel movements, flatulence, oral hypoesthesia, oral paresthesia^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Cardio-respiratory distress, angina pectoris, arrhythmia, palpitations, irregular heart rate, bradycardia, tachycardia, hypotension, chest discomfort
• Very rare (less than 0.01%): Hypertension
• Frequency not reported: Chest pain
• Postmarketing reports: Pallor^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Back pain, muscle spasms, myalgia
• Frequency not reported: Arthralgia, pain in extremity^[Ref]

Nervous system

• Common (1% to 10%): Somnolence, dizziness, dysgeusia
• Uncommon (0.1% to 1%): Headache, motor dysfunction, amnesia, memory impairment, paresthesia, vertigo, tinnitus, feeling jittery
• Very rare (less than 0.01%): Syncope
• Frequency not reported: Tremor, hypoesthesia, ageusia
• Postmarketing reports: Coma, lethargy^[Ref]

Ocular

• Common (1% to 10%): Eye allergy, keratitis, eye pain, ocular discomfort, blurred vision, abnormal vision, ocular hyperemia, conjunctival blanching
• Uncommon (0.1% to 1%): Corneal erosion, corneal edema, blepharitis, corneal deposits (keratic precipitates), conjunctival disorder (papilla) , photophobia, photopsia, eye swelling, eyelid edema, conjunctival edema, dry eye, eye discharge, reduced visual acuity, increased lacrimation, pterygium, erythema of eyelid, meibomianitis, diplopia, glare, eye hypoesthesia, scleral pigmentation, subconjunctival cyst, abnormal sensation in eye, asthenopia
• Very rare (less than 0.01%): Uveitis, miosis
• Frequency not reported: Visual disturbances, madarosis
• Postmarketing reports: Iritis, keratoconjunctivitis sicca^[Ref]

Other

• Uncommon (0.1% to 1%): Pain, feeling abnormal, irritability
• Frequency not reported: Face edema, peripheral edema
• Postmarketing reports: Hypothermia^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Apathy, depression, insomnia, nightmare, nervousness^[Ref]

Renal

• Uncommon (0.1% to 1%): Renal pain
• Frequency not reported: Pollakiuria^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Nasopharyngitis, pharyngitis, sinusitis, dyspnea, bronchial hyperactivity, pharyngolaryngeal pain, dry throat, cough, epistaxis, upper respiratory tract congestion, nasal congestion, rhinorrhea, throat irritation, nasal dryness, postnasal drip, sneezing
• Frequency not reported: Rhinitis, asthma
• Postmarketing reports: Apnea, respiratory depression^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Decreased libido, erectile dysfunction^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Decreased red blood cell, increased blood chloride^[Ref]

Hepatic

• Frequency not reported: Abnormal liver function^[Ref]

See also:

Further information

Simbrinza side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer