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Serevent Diskus Side Effects

Generic name: salmeterol

Medically reviewed by Last updated on Jul 30, 2023.

Note: This document contains side effect information about salmeterol. Some dosage forms listed on this page may not apply to the brand name Serevent Diskus.

Applies to salmeterol: inhalation powder.

Serious side effects of Serevent Diskus

Along with its needed effects, salmeterol (the active ingredient contained in Serevent Diskus) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking salmeterol:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking salmeterol:

Symptoms of overdose

Other side effects of Serevent Diskus

Some side effects of salmeterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to salmeterol: inhalation aerosol, inhalation aerosol with adapter, inhalation powder.


Very common (10% or more): Musculoskeletal pain (12%)

Common (1% to 10%): Arthralgia, articular rheumatism, muscle cramps and spasm, bone and skeletal pain, muscle pain, muscle stiffness, muscle tightness, muscle rigidity, musculoskeletal inflammation

Frequency not reported: Join pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 14%)

Common (1% to 10%): Dizziness, migraines, tremor

Frequency not reported: Sinus headache, paresthesia[Ref]


Common (1% to 10%): Pallor, hypertension, palpitations

Uncommon (0.1% to 1%): Tachycardia

Very rare (less than 0.01%): Arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles)

Frequency not reported: Peripheral vasodilation and a compensatory small increase in heart rate[Ref]


Common (1% to 10%): Skin rashes, urticaria, photodermatitis

Frequency not reported: Contact dermatitis, eczema[Ref]


Common (1% to 10%): Gastrointestinal signs and symptoms, nausea, vomiting, candidiasis mouth/throat, dental discomfort and pain, dyspeptic symptoms, gastrointestinal infections, hyposalivation

Frequency not reported: Oral mucosal abnormality[Ref]


Common (1% to 10%): Transient elevation of hepatic enzymes[Ref]


Common (1% to 10%): Hyperglycemia

Rare (less than 0.1%): Hypokalemia[Ref]


Common (1% to 10%): Conjunctivitis, keratitis[Ref]


Common (1% to 10%): Influenza, ear signs and symptoms, edema and swelling

Frequency not reported: Localized aches and pains, pyrexia of unknown origin[Ref]


Common (1% to 10%): Anxiety

Uncommon (0.1% to 1%): Nervousness

Rare (less than 0.1%): Insomnia

Frequency not reported: Sleep disturbances[Ref]


Common (1% to 10%): Nasal/sinus congestion, rhinitis, asthma, tracheitis/bronchitis, pharyngitis, sinusitis, upper respiratory tract infection, cough, throat irritation, lower respiratory signs and symptoms

Very rare (less than 0.01%): Paradoxical bronchospasm, non specific chest pain, oropharyngeal irritation

Frequency not reported: Bronchospasm

Postmarketing reports: Upper airway symptoms of laryngeal spasm, irritation, or swelling such as stridor or choking[Ref]


Very rare (less than 0.01%): Anaphylactic reactions including edema and angioedema, bronchospasm and anaphylactic shock

Frequency not reported: Immediate hypersensitivity reactions

Postmarketing reports: Anaphylaxis[Ref]


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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.