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Rivastigmine Side Effects

Medically reviewed by Last updated on Mar 25, 2024.

Applies to rivastigmine: oral capsule. Other dosage forms:

Serious side effects of Rivastigmine

Along with its needed effects, rivastigmine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rivastigmine:

More common

Less common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking rivastigmine:

Symptoms of overdose

Other side effects of Rivastigmine

Some side effects of rivastigmine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to rivastigmine: oral capsule, oral solution, transdermal film extended release.


Common (1% to 10%): Hyperhidrosis

Rare (less than 0.1%): Rash

Frequency not reported: Pruritus

Postmarketing reports: Stevens-Johnson syndrome disseminated allergic dermatitis[Ref]


Common (1% to 10%): Hypertension, bradycardia

Uncommon (0.1% to 1%): Hypotension

Rare (0.01% to 0.1%): Angina pectoris

Very rare (less than 0.01%): Cardiac arrhythmia (e.g., bradycardia, atrioventricular block, atrial fibrillation, tachycardia)

Frequency not reported: Sick sinus syndrome[Ref]


Very common (10% or more): Nausea (47%), vomiting (31%)diarrhea (19%), abdominal pain (13%)

Common (1% to 10%): Dyspepsia, salivary hypersecretion, upper abdominal pain, flatulence, eructation

Rare (0.01% to 0.1%): Gastric and duodenal ulcers

Very rare (less than 0.01%): GI hemorrhage, pancreatitis

Frequency not reported: Some cases of severe vomiting were associated with esophageal rupture[Ref]


Common (1% to 10%): Urinary incontinence

Very rare (less than 0.01%): Urinary tract infection[Ref]


Frequency not reported: Elevated liver function tests, hepatitis[Ref]

Nervous system

Very common (10% or more): Tremor (23%), dizziness (21%)

Common (1% to 10%): Somnolence, bradykinesia, dyskinesia, cogwheel rigidity, hypokinesia, vertigo, psychomotor hyperactivity, gait disturbance, Parkinson gait, headache

Uncommon (0.1% to 1%): Syncope, dystonia

Rare (0.01% to 0.1%): Seizures[Ref]


Common (1% to 10%): Insomnia, confusion, depression, anxiety, hallucination, agitation, restlessness, nightmares[Ref]


Common (1% to 10%): Application site erythema, application site irritation (e.g., pruritus, rash)

Postmarketing reports: Application site hypersensitivity, urticaria, blister, allergic dermatitis[Ref]


Very common (10% or more): Anorexia (17%)

Common (1% to 10%): Decreased appetite

Frequency not reported: Dehydration[Ref]


Common (1% to 10%): Asthenia, weight loss, fatigue, malaise, fall[Ref]


Common (1% to 10%): Rhinitis[Ref]


1. (2001) "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals

2. Monastero R, Lopez G, Mannino M, Camarda R (2001) "Erythematous maculopapular eruption due to rivastigmine therapy." Am J Med, 111, p. 583-4

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Kayrak M, Yazici M, Ayhan SS, Koc F, Ulgen MS (2008) "Complete atrioventricular block associated with rivastigmine therapy." Am J Health Syst Pharm, 65, p. 1051-3

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.