Prudoxin Side Effects
Generic name: doxepin topical
Medically reviewed by Drugs.com. Last updated on Apr 27, 2022.
Note: This document contains side effect information about doxepin topical. Some of the dosage forms listed on this page may not apply to the brand name Prudoxin.
Summary
Common side effects of Prudoxin include: application site reaction and drowsiness. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to doxepin topical: topical cream
Side effects requiring immediate medical attention
Along with its needed effects, doxepin topical (the active ingredient contained in Prudoxin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking doxepin topical:
More common
- Burning, crawling, or tingling sensation of the skin
- swelling at the site of application
- worsening of eczema and itching
Rare
- Fever
Symptoms of overdose
- Abdominal pain and swelling
- blurring of vision
- convulsions (seizures)
- decreased awareness or responsiveness
- difficulty in breathing
- difficulty in passing urine
- dizziness, fainting, or lightheadedness
- drowsiness
- enlarged pupils
- excessive dryness of mouth
- extremely high fever or body temperature
- extremely low body temperature
- fast heartbeat
- increased or excessive unconscious or jerking movements
- incurable constipation
- irregular heartbeat
- unconsciousness
- vomiting
- weak pulse
Side effects not requiring immediate medical attention
Some side effects of doxepin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Burning and/or stinging at the site of application
- changes in taste
- dizziness
- drowsiness
- dryness and tightness of skin
- dryness of mouth and/or lips
- emotional changes
- headache
- thirst
- unusual tiredness or weakness
Less common
For Healthcare Professionals
Applies to doxepin topical: topical cream
Local
Very common (10% or more): Burning/stinging (23%)
Common (1% to 10%): Other application site reaction
Frequency not reported: Irritation, tingling[Ref]
Nervous system
Very common (10% or more): Drowsiness (up to 22%)
Common (1% to 10%): Dizziness, taste perversion
Uncommon (0.1% to 1%): Headache
Frequency not reported: Lightheadedness, taste bitter, taste metallic[Ref]
Gastrointestinal
Common (1% to 10%): Dry mouth
Uncommon (0.1% to 1%): Numbness of tongue, nausea
Frequency not reported: Dry lips, dry throat, thirst, indigestion, vomiting, diarrhea, constipation[Ref]
Dermatologic
Common (1% to 10%): Pruritus, eczema exacerbated
Frequency not reported: Localized rash, pruritus exacerbated
Postmarketing reports: Allergic contact dermatitis[Ref]
General
The most frequently reported adverse effects were drowsiness and burning/stinging at application site.[Ref]
Genitourinary
Frequency not reported: Urinary retention[Ref]
Hypersensitivity
Frequency not reported: Type IV hypersensitivity reaction[Ref]
Ocular
Frequency not reported: Blurred vision, dry eyes[Ref]
Other
Common (1% to 10%): Fatigue/tiredness, edema
Uncommon (0.1% to 1%): Fever
Frequency not reported: Vertigo[Ref]
Psychiatric
Common (1% to 10%): Mental emotional changes
Uncommon (0.1% to 1%): Nervousness/anxiety[Ref]
More about Prudoxin (doxepin topical)
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Pricing & coupons
- En español
- Drug class: topical antihistamines
Patient resources
Other brands
Professional resources
Related treatment guides
References
1. "Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc (2001):
2. MHRA. Medicines and Health Regulatory Agency "MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate." (2013):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.