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Prudoxin Side Effects

Generic name: doxepin topical

Medically reviewed by Last updated on May 30, 2023.

Note: This document contains side effect information about doxepin topical. Some dosage forms listed on this page may not apply to the brand name Prudoxin.

Applies to doxepin topical: topical cream.

Serious side effects of Prudoxin

Along with its needed effects, doxepin topical (the active ingredient contained in Prudoxin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking doxepin topical:

More common


Symptoms of overdose

Other side effects of Prudoxin

Some side effects of doxepin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to doxepin topical: topical cream.


Very common (10% or more): Burning/stinging (23%)

Common (1% to 10%): Other application site reaction

Frequency not reported: Irritation, tingling[Ref]

Nervous system

Very common (10% or more): Drowsiness (up to 22%)

Common (1% to 10%): Dizziness, taste perversion

Uncommon (0.1% to 1%): Headache

Frequency not reported: Lightheadedness, taste bitter, taste metallic[Ref]


Common (1% to 10%): Dry mouth

Uncommon (0.1% to 1%): Numbness of tongue, nausea

Frequency not reported: Dry lips, dry throat, thirst, indigestion, vomiting, diarrhea, constipation[Ref]


Common (1% to 10%): Pruritus, eczema exacerbated

Frequency not reported: Localized rash, pruritus exacerbated

Postmarketing reports: Allergic contact dermatitis[Ref]


The most frequently reported adverse effects were drowsiness and burning/stinging at application site.[Ref]


Frequency not reported: Urinary retention[Ref]


Frequency not reported: Type IV hypersensitivity reaction[Ref]


Frequency not reported: Blurred vision, dry eyes[Ref]


Common (1% to 10%): Fatigue/tiredness, edema

Uncommon (0.1% to 1%): Fever

Frequency not reported: Vertigo[Ref]


Common (1% to 10%): Mental emotional changes

Uncommon (0.1% to 1%): Nervousness/anxiety[Ref]


1. (2001) "Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc

2. MHRA. Medicines and Health Regulatory Agency (2013) MHRA Drug Safety Update.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.