Skip to Content

Perjeta Side Effects

Generic Name: pertuzumab

Note: This document contains side effect information about pertuzumab. Some of the dosage forms listed on this page may not apply to the brand name Perjeta.

For the Consumer

Applies to pertuzumab: intravenous solution

Along with its needed effects, pertuzumab (the active ingredient contained in Perjeta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pertuzumab:

More common
  • Black, tarry stools
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • redness of the skin
  • sore throat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Some side effects of pertuzumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • change in taste
  • cracked lips
  • decreased appetite
  • diarrhea
  • dizziness
  • dry skin
  • ear congestion
  • hair loss or thinning of the hair
  • headache
  • loosening of the fingernails
  • loss of taste
  • loss of voice
  • nasal congestion
  • nausea
  • redness or soreness around the fingernails
  • runny nose
  • sneezing
  • vomiting
  • watering of the eyes

For Healthcare Professionals

Applies to pertuzumab: intravenous solution

Cardiovascular

Common (1% to 10%): Left ventricular dysfunction (including congestive heart failure)[Ref]

Dermatologic

Very Common (10% or more): Alopecia (up to 61%), rash (up to 34%), nail disorder (up to 23%), pruritus (up to 14%)
Common (1% to 10%): Dry skin, palmar-plantar erythrodysesthesia syndrome[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 67%), nausea (up to 42%), mucositis/mucosal inflammation (up to 28%), constipation (up to 25%), vomiting (up to 24%), stomatitis (up to 19%), dyspepsia (up to 12%)[Ref]

Hematologic

Very common (10% or more): Neutropenia (up to 53%), anemia (up to 23%), leucopenia (up to 20%), febrile neutropenia (up to 13%)[Ref]

Hypersensitivity

Very common (10% or more): Hypersensitivity/anaphylactic reaction, infusion reaction/cytokine release syndrome[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 29%)[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 24%), arthralgia (up to 15%), pain in extremity (up to 15%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 21%), headache (up to 21%), dysgeusia (up to 18%), peripheral sensory neuropathy (up to 14%), dizziness (up to 13%)[Ref]

Ocular

Very common (10% or more): Increased lacrimation (up to 14%)[Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 13%)[Ref]

Respiratory

Very common (10% or more): Cough (up to 21%), upper respiratory tract infection (up to 17%), dyspnea (up to 16%), nasopharyngitis (up to 13%)
Common (1% to 10%): Paronychia, pleural effusion, epistaxis
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Other

Very common (10% or more): Fatigue (up to 38%), peripheral edema (up to 30%), asthenia (up to 30%), pyrexia (up to 19%), pain
Common (1% to 10%): Chills[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Perjeta (pertuzumab)." Genentech, South San Francisco, CA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of Perjeta may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide