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Perjeta Side Effects

Generic Name: pertuzumab

Note: This page contains side effects data for the generic drug pertuzumab. It is possible that some of the dosage forms included below may not apply to the brand name Perjeta.

In Summary

Common side effects of Perjeta include: anaphylaxis, hypersensitivity, infusion related reaction, and cytokine release syndrome. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pertuzumab: intravenous solution

As well as its needed effects, pertuzumab (the active ingredient contained in Perjeta) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pertuzumab, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • redness of the skin
  • sore throat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Minor Side Effects

Some pertuzumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Body aches or pain
  • change in taste
  • cracked lips
  • decreased appetite
  • diarrhea
  • dizziness
  • dry skin
  • ear congestion
  • hair loss or thinning of the hair
  • headache
  • loosening of the fingernails
  • loss of taste
  • loss of voice
  • nasal congestion
  • nausea
  • redness or soreness around the fingernails
  • runny nose
  • sneezing
  • vomiting
  • watering of the eyes

For Healthcare Professionals

Applies to pertuzumab: intravenous solution


Common (1% to 10%): Left ventricular dysfunction (including congestive heart failure)[Ref]


Very Common (10% or more): Alopecia (up to 61%), rash (up to 34%), nail disorder (up to 23%), pruritus (up to 14%)
Common (1% to 10%): Dry skin, palmar-plantar erythrodysesthesia syndrome[Ref]


Very common (10% or more): Diarrhea (up to 67%), nausea (up to 42%), mucositis/mucosal inflammation (up to 28%), constipation (up to 25%), vomiting (up to 24%), stomatitis (up to 19%), dyspepsia (up to 12%)[Ref]


Very common (10% or more): Neutropenia (up to 53%), anemia (up to 23%), leucopenia (up to 20%), febrile neutropenia (up to 13%)[Ref]


Very common (10% or more): Hypersensitivity/anaphylactic reaction, infusion reaction/cytokine release syndrome[Ref]


Very common (10% or more): Decreased appetite (up to 29%)[Ref]


Very common (10% or more): Myalgia (up to 24%), arthralgia (up to 15%), pain in extremity (up to 15%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 21%), headache (up to 21%), dysgeusia (up to 18%), peripheral sensory neuropathy (up to 14%), dizziness (up to 13%)[Ref]


Very common (10% or more): Increased lacrimation (up to 14%)[Ref]


Very common (10% or more): Insomnia (up to 13%)[Ref]


Very common (10% or more): Cough (up to 21%), upper respiratory tract infection (up to 17%), dyspnea (up to 16%), nasopharyngitis (up to 13%)
Common (1% to 10%): Paronychia, pleural effusion, epistaxis
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]


Very common (10% or more): Fatigue (up to 38%), peripheral edema (up to 30%), asthenia (up to 30%), pyrexia (up to 19%), pain
Common (1% to 10%): Chills[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Perjeta (pertuzumab)." Genentech, South San Francisco, CA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Perjeta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.