Periactin Side Effects
Generic name: cyproheptadine
Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.
Note: This document contains side effect information about cyproheptadine. Some of the dosage forms listed on this page may not apply to the brand name Periactin.
For the Consumer
Applies to cyproheptadine: oral solution, oral tablets
Side effects include:
Sedation, sleepiness (often transient), dizziness, disturbed coordination, restlessness, excitation.
For Healthcare Professionals
Applies to cyproheptadine: compounding powder, oral syrup, oral tablet
General
The most commonly reported side effects included drowsiness and somnolence.[Ref]
Nervous system
Common (1% to 10%): Drowsiness, somnolence
Frequency not reported: Convulsions, coordination disturbance, dizziness, faintness, headache, neuritis, paresthesias, sedation/transient sedation, sleepiness/transient sleepiness, tremor, vertigo[Ref]
Some patients who developed drowsiness initially had an apparent improvement in symptoms when they continued taking this drug continuously over the next 3 to 4 days.[Ref]
Psychiatric
Frequency not reported: Aggressive behavior, confusion, euphoria, excitation, hallucinations, hysteria, insomnia, irritability, nervousness, restlessness[Ref]
Gastrointestinal
Frequency not reported: Constipation, diarrhea, dry mouth, epigastric distress, nausea, vomiting[Ref]
Genitourinary
Frequency not reported: Difficult urination/micturition difficulty, early menses, micturition frequency/urinary frequency, urinary retention[Ref]
Respiratory
Frequency not reported: Chest tightness, dry nose, dry throat, nasal stuffiness, thickened bronchial secretions, wheezing[Ref]
Hepatic
Frequency not reported: Cholestasis, hepatitis, jaundice, liver failure, liver function abnormality[Ref]
Dermatologic
Frequency not reported: Allergic rash, excessive perspiration, photosensitivity, urticaria[Ref]
Cardiovascular
Frequency not reported: Extrasystoles, hypotension, palpitation, tachycardia[Ref]
Hematologic
Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia[Ref]
Metabolic
Frequency not reported: Anorexia, increased appetite, weight gain[Ref]
Other
Frequency not reported: Chills, fatigue, rigors[Ref]
Hypersensitivity
Frequency not reported: Allergic edema, anaphylactic shock[Ref]
Ocular
Frequency not reported: Blurred vision, diplopia[Ref]
Immunologic
Frequency not reported: Acute labyrinthitis[Ref]
More about Periactin (cyproheptadine)
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Reviews (61)
- Drug images
- Drug class: antihistamines
Professional resources
Related treatment guides
References
1. "Product Information. Periactin (cyproheptadine)." Merck & Co, Inc, West Point, PA.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.