Periactin Side Effects

Generic Name: cyproheptadine

Note: This document contains side effect information about cyproheptadine. Some of the dosage forms listed on this page may not apply to the brand name Periactin.

For the Consumer

Applies to cyproheptadine: oral solution, oral tablets

Side effects include:

Sedation, sleepiness (often transient), dizziness, disturbed coordination, restlessness, excitation.

For Healthcare Professionals

Applies to cyproheptadine: compounding powder, oral syrup, oral tablet

Nervous system

Nervous system side effects have commonly included central nervous system (CNS) depression, typically resulting in drowsiness and sedation. These effects have often been transient and often ceased with continued use. Motor skills have been be impaired. Infrequently, confusion, restlessness, nervousness, tremor, convulsions, and hallucinations have occurred.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included dry mouth, diarrhea, constipation, nausea, and vomiting.^[Ref]

Other

The effect of cyproheptadine (the active ingredient contained in Periactin) on weight gain has been studied in patients in whom weight gain would be beneficial, such as those suffering from anorexia nervosa. In healthy, thin individuals, weight gain of 4 kg in 56 days has been reported with a dosage of 12 mg orally per day.^[Ref]

Other side effects have included weight gain. The mechanism of action is not known but appears to be related to appetite stimulation, although a decrease in physical activity resulting from the sedative effect of the drug may contribute to a small degree.^[Ref]

Cardiovascular

Cardiovascular side effects have included hypotension, tachycardia, and palpitations.^[Ref]

Respiratory

Respiratory side effects have included dry nose and throat, thickening of bronchial secretions, chest tightness, and wheezing.^[Ref]

Ocular

Ocular side effects have included blurred vision, diplopia, and dry eyes, due to the anticholinergic activity of the drug.^[Ref]

Genitourinary

Genitourinary side effects have included urinary retention, urinary frequency and dysuria probably resulting from cyproheptadine (the active ingredient contained in Periactin) s anticholinergic activity.^[Ref]

Hematologic

Hematologic side effects have included hemolytic anemia, thrombocytopenia, and agranulocytosis, but these have been uncommon.^[Ref]

Hepatic

Hepatic side effects have included rare reports of cholestatic jaundice.^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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