Oxyfrin Side Effects

Generic name: oxymetazoline nasal

Medically reviewed by Drugs.com. Last updated on Mar 18, 2024.

Note: This document provides detailed information about Oxyfrin Side Effects associated with oxymetazoline nasal. Some dosage forms listed on this page may not apply specifically to the brand name Oxyfrin.

Applies to oxymetazoline nasal: nasal spray.

Serious side effects of Oxyfrin

Along with its needed effects, oxymetazoline nasal (the active ingredient contained in Oxyfrin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal:

• Blurred vision
• fast, irregular, or pounding heartbeat
• headache, dizziness, drowsiness, or lightheadedness
• high blood pressure
• increase in runny or stuffy nose
• nervousness
• trembling
• trouble in sleeping
• weakness

Other side effects of Oxyfrin

Some side effects of oxymetazoline nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Burning, dryness, or stinging inside of nose
• sneezing

For healthcare professionals

Applies to oxymetazoline nasal: nasal solution, nasal spray.

General

The most commonly reported side effects were discomfort or irritation in the nose, mouth or throat, and sneezing.^[Ref]

Gastrointestinal

• Very rare (less than 0.01%): Nausea^[Ref]

Cardiovascular

• Very rare (less than 0.01%): Tachycardia, palpitations, increased blood pressure^[Ref]

Nervous system

• Very rare (less than 0.01%): Insomnia, nervousness, tremor, anxiety, restlessness, irritability, headache^[Ref]

Ocular

• Rare (less than 0.1%): Eye irritation, dryness, discomfort/redness^[Ref]

Respiratory

• Rare (less than 0.1%): Discomfort or irritation in the nose, mouth or throat, sneezing
• Frequency not reported: Rhinitis medicamentosa (after prolonged or heavy use)^[Ref]

Frequently asked questions

• Does Mucinex help with Covid?

Further information

Oxyfrin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer