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Oralair Side Effects

Generic name: mixed grass pollens allergen extract

Medically reviewed by Last updated on Jun 11, 2023.

Note: This document contains side effect information about mixed grass pollens allergen extract. Some dosage forms listed on this page may not apply to the brand name Oralair.

Applies to mixed grass pollens allergen extract: sublingual tablet.


Sublingual route (Tablet)

Use of Sweet Vernal/Orchard/Rye/Timothy/Kentucky Blue Grass mixed pollen allergen extract may lead to life-threatening allergic reactions including anaphylaxis and severe laryngopharyngeal edema. Do not use in patients with severe asthma that is unstable or uncontrolled. Monitor patients for at least 30 minutes after administration of the initial dose. Prescribe auto-injectable epinephrine and instruct on its use, including when to seek immediate medical care. Sweet Vernal/Orchard/Rye/Timothy/Kentucky Blue Grass mixed pollen allergen extract may not be appropriate for patients whose medical conditions decrease their ability to survive a serious allergic reaction or for patients who are unresponsive to epinephrine or inhaled bronchodilators, eg, when receiving beta-blocker therapy.

Serious side effects of Oralair

Along with its needed effects, mixed grass pollens allergen extract (the active ingredient contained in Oralair) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mixed grass pollens allergen extract:

More common

Less common

Incidence not known

Other side effects of Oralair

Some side effects of mixed grass pollens allergen extract may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to mixed grass pollens allergen extract: sublingual tablet.


The most common side effects reported were oral pruritus, throat irritation, ear pruritus, mouth edema, tongue pruritus, cough, oropharyngeal pain.[Ref]


Postmarketing reports: Anaphylactic reaction, oral allergy syndrome, angioedema[Ref]


Very common (10% or more): Throat irritation (22%)

Common (1% to 10%): Cough, oropharyngeal pain, pharyngeal edema, tonsillitis, upper respiratory tract infection, asthma, dysphonia

Postmarketing reports: Dyspnea, laryngeal edema, stridor, wheezing, exacerbation of asthma, oropharyngeal blistering[Ref]


Postmarketing reports: Flushing, eosinophilic myocarditis, palpitations, tachycardia, hypotension, circulatory collapse, pallor, peripheral vascular disorder, chest discomfort[Ref]


Common (1% to 10%): Urticaria, atopic dermatitis

Postmarketing reports: Rash, pruritus[Ref]


Postmarketing reports: Autoimmune thyroiditis[Ref]


Very common (10% or more): Oral pruritus (25.1%)

Common (1% to 10%): Mouth edema, tongue pruritus, lip edema, oral paresthesia, abdominal pain, dyspepsia, tongue edema, oral hypoesthesia, stomatitis, dysphagia, nausea, vomiting, esophageal pain, gastritis, gastroesophageal reflux, lip pruritus

Postmarketing reports: Diarrhea, eosinophilic esophagitis, salivary gland enlargement and/or hypersecretion, dry mouth, dry eye[Ref]


Postmarketing reports: Lymphoadenopathy, increased eosinophilic count[Ref]


Postmarketing reports: Decreased weight[Ref]

Nervous system

Postmarketing reports: Loss of consciousness, headache, somnolence, dizziness[Ref]


Common (1% to 10%): Ear pruritus

Postmarketing reports: Malaise, face edema, tinnitus, asthenia, influenza-like illness[Ref]


Postmarketing reports: Anxiety[Ref]


1. (2014) "Product Information. Oralair (mixed grass pollens allergen extract)." Greer Laboratories Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.