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Optison Side Effects

Generic Name: perflutren

Note: This page contains side effects data for the generic drug perflutren. It is possible that some of the dosage forms included below may not apply to the brand name Optison.

For the Consumer

Applies to perflutren: intravenous suspension

As well as its needed effects, perflutren (the active ingredient contained in Optison) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking perflutren, check with your doctor or nurse immediately:

Less common:
  • Chest pain
  • feeling of warmth
  • fever or chills
  • redness of the face, neck, arms, and occasionally, upper chest
  • trouble breathing
Rare
  • Hives or welts, itching, or skin rash
  • fast, irregular, pounding, or racing heartbeat or pulse
  • redness of the skin
Incidence not known:
  • Blurred vision
  • chest discomfort
  • cold, clammy skin
  • confusion
  • convulsions
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fast, weak pulse
  • feeling of warmth
  • headache
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • nervousness
  • no blood pressure or pulse
  • noisy breathing
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • stopping of heart
  • sweating
  • tightness in the chest
  • troubled swallowing
  • unconsciousness
  • unusual tiredness or weakness

Minor Side Effects

Some perflutren side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • cough
  • discomfort at the injection site
  • nausea or vomiting
  • sore throat
  • stuffy or runny nose
Rare
  • Back pain
  • body or muscle aches
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in color vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with moving
  • difficulty seeing at night
  • discoloration of the skin at the injection site
  • dry mouth
  • hearing loss
  • increased sensitivity of the eyes to sunlight
  • muscle pain or stiffness

For Healthcare Professionals

Applies to perflutren: intravenous suspension

General

The most frequently reported adverse reactions were headache, nausea and/or vomiting, warm sensation or flushing, dizziness, and back pain.[Ref]

Cardiovascular

Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Abnormal ECGs, bradycardia, tachycardia, palpitation, hypertension, hypotension
Postmarketing reports: Fatal cardiac arrest, shock, syncope, symptomatic arrhythmias (atrial fibrillation, tachycardia, bradycardia, supraventricular tachycardia, ventricular fibrillation/tachycardia), hypertension, hypotension[Ref]

Serious but uncommon cardiopulmonary reactions, including fatalities, have been reported during or following administration of this medication. Most serious reactions occurred within 30 minutes of administration.

QTc prolongation of greater than 30 milliseconds occurred in 29% (64/221) of patients evaluated. Of these patients 72% (46/64) were further evaluated and 39% (18/46) were found to have cardiac rhythm changes. (Definity(R))[Ref]

Respiratory

Uncommon (0.1% to 1%): Coughing, hypoxia, pharyngitis, rhinitis, dyspnea
Postmarketing reports: Fatal respiratory arrest, dyspnea, hypoxia, respiratory distress, stridor, wheezing[Ref]

Hypersensitivity

Postmarketing reports: Anaphylactic/anaphylactoid reactions[Ref]

Postmarketing reports of anaphylactic/anaphylactoid reactions have included: anaphylactic shock, hypersensitivity, bronchospasm, throat tightness, angioedema, edema (pharyngeal, palatal, mouth, peripheral, localized), swelling (face, eye, lip, tongue, upper airway), facial hypoesthesia, rash, urticaria, pruritus, flushing, and erythema.[Ref]

Dermatologic

Common (1% to 10%): Flushing
Uncommon (0.1% to 1%): Pruritus, rash, erythematous rash, urticaria, increased sweating, dry skin[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Dyspepsia, dry mouth, tongue disorder, abdominal pain, diarrhea, vomiting[Ref]

Genitourinary

Uncommon (0.1% to 1%): Albuminuria[Ref]

Hematologic

Uncommon (0.1% to 1%): Granulocytosis, leukocytosis, leukopenia, eosinophilia, hematoma[Ref]

Local

Uncommon (0.1% to 1%): Injection site reaction[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Arthralgia[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Leg cramps, hypertonia, vertigo, paresthesia, dizziness, taste perversion
Postmarketing Reports: Coma, loss of consciousness, convulsion, seizure, transient ischemic attack, agitation, tremor, vision blurred, dizziness, headache, fatigue[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, abnormal vision[Ref]

Other

Uncommon (0.1% to 1%): Decreased hearing[Ref]

Renal

Common (1% to 10%): Renal pain[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Definity (perflutren)." Lantheus Medical Imaging Inc, North Billerica, MA.

3. "Product Information. Optison (perflutren)." Mallinckrodt Medical Inc, St. Louis, MO.

It is possible that some side effects of Optison may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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