Optison Dosage

Adults

• The recommended dose in adults is 0.5 mL administered intravenously at a rate not exceeding 1 mL/s.
• If the contrast enhancement is inadequate after the dose of 0.5 mL, additional doses of 0.5 mL may be repeated for further contrast enhancement as needed.
• The maximum total dose is 5 mL in any 10-minute period.
• The maximum total dose is 8.7 mL in any one patient study.

​Pediatric Patients

• ​The recommended dose by body weight in pediatric patients is shown in Table 1.
• ​Administer by intravenous injection at a rate not exceeding 0.05 mL/s.
• ​If the contrast enhancement is inadequate after the initial dose, up to four additional doses of the same diluted volume may be repeated for further contrast enhancement as needed.
• ​OPTISON must be diluted with 0.9% Sodium Chloride Injection to form a 1:1 dilution for pediatric administration.

  Table 1. Recommended Dose of OPTISON by Body Weight in Pediatric Patients

  ​Body Weight	Dose
  ​28 kg or less	0.2 mL of OPTISON diluted with 0.2 mL of 0.9% Sodium Chloride Injection
  ​29 kg to 40 kg	0.3 mL of OPTISON diluted with 0.3 mL of 0.9% Sodium Chloride Injection
  ​41 kg or more	0.4 mL of OPTISON diluted with 0.4 mL of 0.9% Sodium Chloride Injection

General

• Visually inspect the OPTISON vial. Do not use if the container has been damaged, the protective seal and/or rubber cap have been entered, or the upper white layer is absent (may indicate the microspheres have been damaged and may result in poor or no echo contrast).
• Invert the vial and gently rotate to resuspend the microspheres. This process will allow the product to come to room temperature (20°C to 25°C or 68°F to 77°F) before use.
• Inspect the vial for complete resuspension. Do not use if the suspension appears to be clear rather than opaque and milky-white.
• Vent the OPTISON vial with a sterile vent spike or with a sterile 18-gauge needle before withdrawing the OPTISON suspension into the injection syringe.
• Do not inject air into the vial.
• Use the product within one minute of suspension. If one minute is exceeded, resuspend by inverting and gently rotating the syringe for no less than 10 seconds. Failure to adequately resuspend OPTISON may cause inadequate delivery of the microspheres and may result in inadequate contrast.

​Dilution for Pediatric Administration

• ​Invert the OPTISON vial and gently rotate to resuspend the microspheres.
• ​Draw equal volumes of OPTISON and 0.9% Sodium Chloride Injection into the same syringe to form a 1:1 dilution.
• ​Mix gently by holding the syringe horizontally between the palms and rolling it gently back and forth for at least 10 seconds.
• ​If not used within 10 minutes after dilution, discard the diluted product.