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Generic name: perflutrenper-FLOO-tren ]
Brand names: Definity, Definity RT, Optison
Drug class: Ultrasound contrast media

Medically reviewed by on Dec 15, 2022. Written by Cerner Multum.

What is Optison?

Optison is an ultrasound contrast agent that is used to improve the quality of an echocardiogram (ultrasound of the heart). This medicine works by changing the way ultrasound waves travel within your heart. This helps the ultrasound portray a sharper image of your heart.

Optison is used to allow certain segments of the heart to be seen more clearly on an echocardiogram.

Optison may also be used for purposes not listed in this medication guide.

Optison side effects

Get emergency medical help if you have signs of an allergic reaction: hives, skin redness, itching; warmth, redness, numbness, or tingly feeling; wheezing, trouble breathing, tightness in your chest or throat; swelling of your face, lips, tongue, or throat.

In rare cases, serious or fatal reactions may occur during the injection or shortly afterward. Tell your caregivers right away if you have:

You may be more likely to have a serious reaction if you have severe or uncontrolled heart problems (congestive heart failure, a recent heart attack, serious heart rhythm disorder).

Common side effects of Optison may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Serious side effects may occur during the injection. Tell your caregiver if you feel dizzy, nauseated, light-headed, short of breath, or if you have a severe headache, pounding in your ears, chest pain, fast or slow heartbeats, wheezing, or shallow breathing.

You may be more likely to have a serious reaction if you have severe or uncontrolled heart problems (congestive heart failure, a recent heart attack, serious heart rhythm disorder).

Before taking this medicine

You should not be treated with Optison if you are allergic to Optison, polyethylene glycol or albumin.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is Optison given?

Optison is given as an infusion into a vein. A healthcare provider will give you this injection just before the start of your echocardiogram.

Your heart rate, breathing, blood pressure, oxygen levels, and other vital signs will be watched closely for at least 30 minutes after you receive Optison. This is to make sure you do not have an allergic reaction to the medicine.

What happens if I miss a dose?

Since Optison is given with an echocardiogram, you will not be on a regular dosing schedule.

What happens if I overdose?

Since Optison is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Optison?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Optison?

Other drugs may affect Optison, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.