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Norzine Side Effects

Generic Name: thiethylperazine

Note: This page contains side effects data for the generic drug thiethylperazine. It is possible that some of the dosage forms included below may not apply to the brand name Norzine.

For the Consumer

Applies to thiethylperazine: solution, suppository, tablet

As well as its needed effects, thiethylperazine (the active ingredient contained in Norzine) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking thiethylperazine, check with your doctor or nurse as soon as possible:

Less common or rare:
  • Abdominal or stomach pains
  • aching muscles and joints
  • blurred vision, change in color vision, or difficulty in seeing at night
  • confusion (especially in the elderly)
  • convulsions (seizures)
  • difficulty in speaking or swallowing
  • fast heartbeat
  • fever and chills
  • inability to move eyes
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • muscle spasms (especially of face, neck, and back)
  • nausea, vomiting, or diarrhea
  • nightmares (continuing)
  • nosebleeds
  • puffing of cheeks
  • rapid or fine, worm-like movements of tongue
  • shuffling walk
  • skin itching (severe)
  • sore throat and fever
  • stiffness of arms or legs
  • swelling of arms, hands, and face
  • tic-like or twitching movements
  • trembling and shaking of hands and fingers
  • twisting movements of body
  • uncontrolled chewing movements
  • uncontrolled movements of arms or legs
  • unusual bleeding or bruising
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual tiredness or weakness
  • weakness of arms and legs
  • yellow eyes or skin
Symptoms of overdose:
  • Confusion (severe)
  • convulsions (seizures)
  • dizziness (severe)
  • drowsiness (severe)
  • dry mouth (severe)
  • hyperextension of neck and trunk
  • inability to move eyes
  • loss of consciousness
  • spasms of face and neck
  • stuffy nose
  • troubled breathing

Minor Side Effects

Some thiethylperazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Dizziness
  • drowsiness
Less common or rare:
  • Constipation
  • dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • dryness of mouth, nose and throat
  • fainting
  • fever
  • headache
  • ringing or buzzing in ears
  • skin rash

For Healthcare Professionals

Applies to thiethylperazine: intramuscular solution, oral tablet

Nervous system

Nervous system side effects have included sedation, dizziness, or headache. Extrapyramidal reactions have been reported in less than 1% of patients and included dystonia, torticollis, oculogyric crises, akathisia, and gait disturbances. Pseudo-parkinsonian reactions including mask-like facies, drooling, cogwheel rigidity, and shuffling gait have been reported. Convulsions have also been reported rarely. Neuroleptic malignant syndrome has been reported with other phenothiazines, and the potential to occur with thiethylperazine (the active ingredient contained in Norzine) should be considered.[Ref]

Gastrointestinal

Gastrointestinal side effects have included dryness of the mouth and nose, sialorrhea, and altered taste sensation.[Ref]

Hepatic

Hepatic side effects have rarely included the development of cholestatic jaundice.[Ref]

Hematologic

Hematologic side effects associated with phenothiazine derivatives have rarely included leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, pancytopenia, eosinophilia, and leukocytosis.[Ref]

Cardiovascular

Cardiovascular side effects have included hypotension during intravenous administration.[Ref]

Dermatologic

Dermatologic side effects have rarely included erythema, exfoliative dermatitis, and contact dermatitis.[Ref]

Ocular

Ocular side effects have included blurred vision.[Ref]

Hypersensitivity

Hypersensitivity side effects including at least one case of anaphylactic reaction have been reported.[Ref]

A 15-year-old female was admitted for angioedema and respiratory distress coincident with thiethylperazine therapy. She had been prescribed thiethylperazine (total of three doses) for abdominal pain and heavy nausea lasting for 2 days. Three hours after the last dose, she began to complain of face and tongue edema, speech difficulties, and dysphagia. On physical examination, she was in good general condition and showed an angioedema and erythema of the face, the upper thorax, and the tongue. An anaphylactic reaction was suspected and treatment was initiated. Her symptoms improved after treatment with intravenous biperiden, two aerosols of albuterol and budesonide, and intravenous methylprednisolone.[Ref]

References

1. "Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.

2. Rossetti G, Livio F, Roulet E, Hofer MF "Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine." Pediatr Allergy Immunol 16 (2005): 453-5

It is possible that some side effects of Norzine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Norzine (thiethylperazine)

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