Norzine Side Effects
Generic name: thiethylperazine
Medically reviewed by Drugs.com. Last updated on Oct 1, 2022.
Note: This document contains side effect information about thiethylperazine. Some dosage forms listed on this page may not apply to the brand name Norzine.
Applies to thiethylperazine: intramuscular solution, oral tablet.
Nervous system side effects have included sedation, dizziness, or headache. Extrapyramidal reactions have been reported in less than 1% of patients and included dystonia, torticollis, oculogyric crises, akathisia, and gait disturbances. Pseudo-parkinsonian reactions including mask-like facies, drooling, cogwheel rigidity, and shuffling gait have been reported. Convulsions have also been reported rarely. Neuroleptic malignant syndrome has been reported with other phenothiazines, and the potential to occur with thiethylperazine (the active ingredient contained in Norzine) should be considered.[Ref]
Hematologic side effects associated with phenothiazine derivatives have rarely included leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, pancytopenia, eosinophilia, and leukocytosis.[Ref]
Ocular side effects have included blurred vision.[Ref]
A 15-year-old female was admitted for angioedema and respiratory distress coincident with thiethylperazine therapy. She had been prescribed thiethylperazine (total of three doses) for abdominal pain and heavy nausea lasting for 2 days. Three hours after the last dose, she began to complain of face and tongue edema, speech difficulties, and dysphagia. On physical examination, she was in good general condition and showed an angioedema and erythema of the face, the upper thorax, and the tongue. An anaphylactic reaction was suspected and treatment was initiated. Her symptoms improved after treatment with intravenous biperiden, two aerosols of albuterol and budesonide, and intravenous methylprednisolone.[Ref]
More about Norzine (thiethylperazine)
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- Drug class: phenothiazine antiemetics
Related treatment guides
1. "Product Information. Torecan (thiethylperazine)." Roxane Laboratories Inc (2001):
2. Rossetti G, Livio F, Roulet E, Hofer MF "Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine." Pediatr Allergy Immunol 16 (2005): 453-5
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