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Ninlaro Side Effects

Generic Name: ixazomib

Note: This page contains side effects data for the generic drug ixazomib. It is possible that some of the dosage forms included below may not apply to the brand name Ninlaro.

In Summary

Common side effects of Ninlaro include: constipation, diarrhea, macular eruption, maculopapular rash, nausea, peripheral edema, peripheral neuropathy, peripheral sensory neuropathy, skin rash, and vomiting. Other side effects include: hepatic insufficiency. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ixazomib: oral capsule

As well as its needed effects, ixazomib (the active ingredient contained in Ninlaro) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ixazomib, check with your doctor immediately:

More common:
  • Abdominal or stomach pain
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chills
  • cough
  • dark urine
  • diarrhea
  • dizziness
  • fever
  • headache
  • itching or rash
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • nausea
  • numbness, tingling, or pain in the hands or feet
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • redness or discoloration of the skin
  • sore throat
  • tingling of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting of blood
  • yellow eyes or skin
Less common:
  • Bleeding gums
  • blood in the urine or stools
Rare
  • Blistering, peeling, or loosening of the skin
  • bloody nose
  • heavier menstrual periods
  • joint or muscle pain
  • red skin lesions, often with a purple center
  • red, irritated eyes

Minor Side Effects

Some ixazomib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • blurred vision
  • body aches or pain
  • burning, dry, or itching eyes
  • difficulty having a bowel movement (stool)
  • discharge, excessive tearing
  • ear congestion
  • loss of voice
  • nasal congestion
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sneezing

For Healthcare Professionals

Applies to ixazomib: oral capsule

Cardiovascular

Very common (10% or more): Peripheral edema (18%)[Ref]

Dermatologic

Very common (10% or more): Rash (11%)
Postmarketing reports: Acute febrile neutrophilic dermatosis (Sweet's syndrome), Stevens-Johnson syndrome[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (36%), constipation (25%), nausea (21%)[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (78%), neutropenia (67%), thrombotic thrombocytopenic purpura[Ref]

Hepatic

Frequency not reported: Hepatotoxicity[Ref]

Immunologic

Postmarketing reports: Transverse myelitis[Ref]

Metabolic

Postmarketing reports: Tumor lysis syndrome[Ref]

Musculoskeletal

Very common (10% or more): Back pain (16%)[Ref]

Nervous system

Frequency not reported: Peripheral neuropathy (21%)
Postmarketing reports: Posterior reversible encephalopathy syndrome[Ref]

Ocular

Common (1% to 10%): Blurred vision, dry eye, conjunctivitis[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (14%)[Ref]

References

1. "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America, Lincolnshire, IL.

It is possible that some side effects of Ninlaro may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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