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Nepafenac ophthalmic Side Effects

For the Consumer

Applies to nepafenac ophthalmic: ophthalmic suspension

Along with its needed effects, nepafenac ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nepafenac ophthalmic:

More Common

  • Blurred vision
  • change in vision
  • decrease in vision
  • loss of vision

Less Common

  • Eye pain
  • itching of the eye
  • swelling and/or redness of the eye and lining of the eyelid

Some side effects of nepafenac ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Feeling of having something in the eye
  • sticky sensation of the eyelids

Less Common

  • Change in color vision
  • cough
  • crusting in the corner of the eye
  • difficulty seeing at night
  • dizziness
  • dry eyes
  • fever
  • headache
  • increased sensitivity of the eyes to sunlight
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • slow or fast heartbeat
  • stuffy or runny nose
  • tenderness around the eyes and cheekbones
  • tightness of the chest or wheezing
  • troubled breathing

For Healthcare Professionals

Applies to nepafenac ophthalmic: ophthalmic suspension


The most commonly reported side effects were capsular opacity, decreased visual acuity, foreign body sensation, increased intraocular pressure, and sticky sensation.[Ref]


Common (1% to 10%): Capsular opacity, reduced visual acuity, foreign body sensation in the eyes, increased intraocular pressure, sticky sensation, conjunctival edema, corneal edema, dry eye, ocular discomfort, photophobia, vitreous detachment

Uncommon (0.1% to 1%): Keratitis, punctate keratitis, corneal epithelium defect, eyelid margin crusting

Rare (less than 0.1%): Iritis, choroidal effusion, corneal deposits, eye pain, ocular hyperemia, blepharitis, eye pruritus, eye discharge, allergic conjunctivitis, increased lacrimation, conjunctival hyperemia

Frequency not reported: Corneal perforation, impaired healing (cornea), corneal opacity, corneal scar, eye irritation, eye swelling, ulcerative keratitis, corneal thinning, blurred vision, delayed healing[Ref]


Common (1% to 10%): Hypertension[Ref]


Common (1% to 10%): Nausea, vomiting[Ref]


Common (1% to 10%): Sinusitis[Ref]


Rare (less than 0.1%): Cutis laxa (dermatochalasis), allergic dermatitis[Ref]


Rare (less than 0.1%): Hypersensitivity[Ref]

Nervous system

Rare (less than 0.1%): Dizziness[Ref]


Frequency not reported: Bleeding time increased


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Nevanac (nepafenac ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.