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Nabilone Side Effects

Medically reviewed by Last updated on Apr 1, 2024.

Applies to nabilone: oral capsules.

Side effects include:

Adverse effects may be similar to those of marijuana (cannabis) and other cannabinoids.

Drowsiness, vertigo, dry mouth, ataxia, euphoria (i.e., feeling “high”), dysphoria, sleep disturbances, headache.

For Healthcare Professionals

Applies to nabilone: oral capsule.

Nervous system

Very common (10% or more): Drowsiness (up to 66%), vertigo/dizziness (up to 59%), ataxia (up to 14%), concentration difficulties (up to 12%)

Common (1% to 10%): Headache, sedation

Frequency not reported: Syncope, cerebral vascular accident, equilibrium dysfunction, paresthesia, tremor, memory disturbance, perception disturbance, convulsions, dystonia, numbness, akathisia, speech disorder, hyperactivity, lightheadedness, coordination disturbance, taste change, nervousness, unconsciousness, hypotonia

Postmarketing reports: CNS depression, CNS stimulation, stupor[Ref]


Very common (10% or more): Euphoria (up to 38%), depression (up to 14%), sleep disturbance (up to 11%)

Common (1% to 10%): Dysphoria, disorientation, depersonalization syndrome

Frequency not reported: Hallucinations, confusion, anxiety, abnormal dreams, insomnia, mood swings, inebriated feeling, psychosis, paranoia, apathy, thought disorder, withdrawal, panic disorder, phobic neurosis, emotional disorder

Postmarketing reports: Emotional lability[Ref]


Common (1% to 10%): Dry mouth (up to 36%)

Uncommon (0.1% to 1%): Nausea

Frequency not reported: Vomiting, diarrhea, abdominal pain, constipation, aphthous ulcer, mouth irritation, gastritis, dyspepsia, thick tongue[Ref]


Very common (10% or more): Visual disturbance (up to 13%)

Frequency not reported: Eye irritation, eye dryness, eye disorder, amblyopia, eye swelling, eyelid disease, pupil dilation, photophobia, visual field defect[Ref]


Common (1% to 10%): Hypotension

Frequency not reported: Orthostatic hypotension, tachycardia, palpitation, hypertension, arrhythmia, elevated supine and standing heart rates[Ref]


Common (1% to 10%): Asthenia

Frequency not reported: Ear tightness, tinnitus, flushing, hot flashes, bacterial infection, unspecified pain, chest pain, fatigue, chills, malaise, irritability, fever, inhibited walking, face edema, lack of effect[Ref]


Frequency not reported: Anemia

Postmarketing reports: Leukopenia[Ref]


Frequency not reported: Muscle pain, back pain, neck pain, joint pain, twitches[Ref]


Frequency not reported: Increased urination, decreased urination, urinary retention, micturition frequency, impaired urination[Ref]


Common (1% to 10%): Anorexia, increased appetite

Frequency not reported: Thirst[Ref]


Frequency not reported: Dyspnea, pharyngitis, nasal congestion, sinus headache, dry throat, dry nose, sneezing, nosebleed, cough, voice change[Ref]


Frequency not reported: Anhidrosis, photosensitivity, pruritus, rash, allergic reactions, excessive sweating[Ref]


1. Product Information. Cesamet (nabilone). Valeant Pharmaceuticals. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.