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Monistat 1 Vaginal Ointment Side Effects

Generic name: tioconazole topical

Medically reviewed by Last updated on Apr 16, 2024.

Note: This document contains side effect information about tioconazole topical. Some dosage forms listed on this page may not apply to the brand name Monistat 1 Vaginal Ointment.

Applies to tioconazole topical: intravaginal ointment.

Side effects include:

Vulvovaginal burning, irritation, vaginitis, pruritus, headache.

For Healthcare Professionals

Applies to tioconazole topical: vaginal ointment w/applicator.


Topical solution:

-Common (1% to 10%): Peripheral edema

-Frequency not reported: Pain[Ref]


Topical solution:

-Uncommon (0.1% to 1%): Rash, dermatitis

-Frequency not reported: Bullous eruption, contact dermatitis, dry skin, nail disorder (including nail discoloration, periungual inflammation, nail pain), pruritus, skin irritation, skin exfoliation, urticaria[Ref]


Topical solution:

-Frequency not reported: Local irritation (including local allergic reactions)

Vaginal ointment:

-Frequency not reported: Burning, itching, pain, irritation, dryness[Ref]

Topical solution: Local irritation (including local allergic reactions) usually occurred during the first week of therapy and was transient and mild.[Ref]


Vaginal ointment:

-Frequency not reported: Increased vaginal burning, increased vaginal itching, increased vaginal irritation, vaginal swelling/redness, difficulty/burning on urination[Ref]


Vaginal ointment:

-Frequency not reported: Abdominal pain/cramping[Ref]


Topical solution:

-Frequency not reported: Allergic reaction

Other formulations than the dermatological preparation:

-Frequency not reported: Anaphylactoid reactions[Ref]

Nervous system

Topical solution:

-Frequency not reported: Paresthesia

Vaginal ointment:

-Frequency not reported: Headache[Ref]


Topical solution:

-Frequency not reported: Periorbital edema[Ref]


Vaginal ointment:

-Frequency not reported: Upper respiratory infection[Ref]

More about Monistat 1 Vaginal Ointment (tioconazole topical)

Patient resources

Other brands


Professional resources

Related treatment guides


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Stein GE, Gurwith D, Mummaw N, Gurwith M (1986) "Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis." Antimicrob Agents Chemother, 29, p. 969-71

3. Clissold SP, Heel RC (1986) "Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses." Drugs, 31, p. 29-51

4. (2022) "Product Information. Vagistat-1 (tioconazole topical)." Bristol-Myers Squibb

5. Onayemi O, Aldridge RD, Shaw S (1992) "Allergic contact dermatitis from tioconazole. A report of 2 cases." Contact Dermatitis, 26, p. 193-4

6. Stubb S, Heikkila H, Reitamo S, Forstrom L (1992) "Contact allergy to tioconazole." Contact Dermatitis, 26, p. 155-8

7. Izu R, Aguirre A, Gonzalez M, Diaz-Perez JL (1992) "Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles." Contact Dermatitis, 26, p. 130-1

8. Jones SK, Kennedy CT (1990) "Contact dermatitis from tioconazole." Contact Dermatitis, 22, p. 122-3

9. Gibson G, Buckley A, Murphy GM (1994) "Allergic contact dermatitis from tioconazole without cross- sensitivity to other imidazoles." Contact Dermatitis, 30, p. 308

10. Quirino AP, Barros MA (1994) "Contact dermatitis from tioconazole." Contact Dermatitis, 30, p. 240-1

11. Piletta P, Pasche-Koo F, Saurat JH (1993) "Contact dermatitis from tioconazole mimicking "one hand two feet syndrome"." Contact Dermatitis, 28, p. 308

12. Marren P, Powell S (1992) "Contact sensitivity to tioconazole and other imidazoles." Contact Dermatitis, 27, p. 129-30

13. Brunelli D, Vincenzi C, Morelli R, Tosti A (1992) "Contact dermatitis from tioconazole." Contact Dermatitis, 27, p. 120

14. Faria A, Goncalo S, Goncalo M, Freitas C, Baptista PP (1996) "Allergic contact dermatitis from tioconazole." Contact Dermatitis, 35, p. 250-2

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.