Mogamulizumab Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 27, 2024.

Applies to mogamulizumab: intravenous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 3 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

This medicine may increase your risk of infections. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever, chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Serious side effects of mogamulizumab

Along with its needed effects, mogamulizumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking mogamulizumab:

Other side effects of mogamulizumab

Some side effects of mogamulizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to mogamulizumab: intravenous solution.

General adverse events

The most common adverse reactions (reported in 20% or more of patients)

were rash (including drug eruption), infusion related reactions, fatigue, diarrhea, upper respiratory tract infection. and musculoskeletal pain. Adverse reactions reported in 10% or more of patients included skin infection, pyrexia, nausea,

edema, thrombocytopenia, headache, constipation, mucositis, anemia, cough, and hypertension.^[Ref]

Immunologic

• Common (1% to 10%): Candidiasis, urinary tract infection, folliculitis, pneumonia, otitis, herpesvirus infection
• Postmarketing reports: Hepatitis B virus reactivation^[Ref]

Local

• Very common (10% or more): Infusion reaction (33%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (e.g., back pain, bone pain, musculoskeletal chest pain, musculoskeletal pain, myalgia, neck pain, pain in extremity) (22%)
• Common (1% to 10%): Muscle spasm^[Ref]

Ocular

• Common (1% to 10%): Conjunctivitis^[Ref]

Metabolic

• Very common (10% or more): Albumin decreased (34%), calcium decreased (30%), uric acid increased (29%), phosphate decreased (27%)
• Common (1% to 10%): Hyperglycemia, hyperuricemia, hypomagnesemia, weight gain, weight loss, anorexia^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, depression^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Tumor lysis syndrome

Respiratory

• Very common (10% or more): Upper respiratory tract infection (e.g., laryngitis viral, nasopharyngitis, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, viral upper respiratory tract infection) (22%), cough (11%)
• Common (1% to 10%): Dyspnea^[Ref]

Other

• Very common (10% or more): Fatigue (31%), pyrexia (17%), edema (16%)
• Common (1% to 10%): Chills, fall^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (14%), anemia (12%)^[Ref]

Nervous system

• Very common (10% or more): Headache (14%)
• Common (1% to 10%): Dizziness, peripheral neuropathy^[Ref]

Renal

• Common (1% to 10%): Renal insufficiency^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (10%)
• Common (1% to 10%): Arrhythmia
• Uncommon (0.1% to 1%): Myocardial infarction, myocardial infarction, cardiac failure
• Postmarketing reports: Stress cardiomyopathy^[Ref]

Dermatologic

• Very common (10% or more): Rash (dermatitis [e.g., allergic, atopic, bullous, contact, exfoliative, infected); drug eruption [e.g., palmoplantar keratoderma]; rash [e.g., generalized, macular, maculopapular, papular, pruritic, pustular]; skin reaction [e.g., toxic skin eruption]) (35%), drug eruption (24%), skin infection (e.g., cellulitis, dermatitis infected, erysipelas, impetigo, infected skin ulcer, periorbital cellulitis, skin bacterial infection, skin infection, staphylococcal skin infection) (22%)
• Common (1% to 10%): Xerosis, alopecia^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (28%), mucositis (e.g., aphthous stomatitis, mouth ulceration, mucosal inflammation, oral discomfort, oral pain, oropharyngeal pain, stomatitis) (17%), nausea (16%), constipation (13%)
• Common (1% to 10%): Vomiting, abdominal pain^[Ref]

See also:

Frequently asked questions

• What is Poteligeo used to treat?

Further information

Mogamulizumab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer