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Methohexital Side Effects

Applies to methohexital: injectable powder for injection, intravenous solution.


Avoid driving or operating machinery for 8 to 12 hours after you awake from anesthesia.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methohexital: injectable powder for injection, intravenous powder for injection, intravenous solution.


Frequency not reported: Circulatory depression, hypotension, tachycardia, peripheral vascular collapse, convulsions (associated with cardiorespiratory arrest)[Ref]


Frequency not reported: Respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, dyspnea, rhinitis[Ref]

Nervous system

Frequency not reported: Injury to nerves adjacent to injection site, seizure, headache[Ref]


Frequency not reported: Emergence delirium, restlessness, and anxiety (especially in the presence of postoperative pain)[Ref]


Frequency not reported: Nausea, vomiting, abdominal pain, salivation[Ref]


Rare (less than 0.1%): Anaphylaxis[Ref]


Frequency not reported: Liver function tests abnormal[Ref]


Frequency not reported: Injection site pain[Ref]


Frequency not reported: Thrombophlebitis[Ref]


Frequency not reported: Skeletal muscle hyperactivity (twitching)[Ref]


Frequency not reported: Erythema, pruritus, urticaria[Ref]


1. Product Information. Brevital Sodium (methohexital). Par Pharmaceutical Inc. 2011.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.