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Makena Side Effects

Generic Name: hydroxyprogesterone

Note: This document contains side effect information about hydroxyprogesterone. Some of the dosage forms listed on this page may not apply to the brand name Makena.

In Summary

Common side effects of Makena include: urticaria and swelling at injection site. Other side effects include: pruritus. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydroxyprogesterone: parenteral injection for im use

Side effects include:

Injection site reactions (pain, swelling, pruritus, nodule), urticaria, pruritus, nausea, diarrhea.

For Healthcare Professionals

Applies to hydroxyprogesterone: compounding powder, intramuscular solution, subcutaneous solution

Genitourinary

Genitourinary side effects have included admission for preterm labor, preeclampsia or gestational hypertension, gestational diabetes, and oligohydramnios. Postmarketing side effects include urinary tract infection, cervical incompetence, premature rupture of membranes, cervical dilation, and shortened cervix.[Ref]

Local

Local side effects have included injection site pain, swelling, pruritus, and nodules. Postmarketing side effects include local injection site reactions of erythema, urticaria, rash, irritation, hypersensitivity, and warmth.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and diarrhea. Postmarketing side effects include vomiting.[Ref]

Dermatologic

Dermatologic side effects have included pruritus and urticaria. Postmarketing side effects include rash.[Ref]

Nervous system

Nervous system side effects include postmarketing reports of headache and dizziness.

Respiratory

Respiratory side effects include postmarketing reports of dyspnea and chest discomfort.

Other

Other side effects include postmarketing reports of fatigue, fever, and hot flashes/flushes.

References

1. "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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