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M-Zole 3 Side Effects

Generic name: miconazole topical

Medically reviewed by Last updated on Sep 19, 2023.

Note: This document contains side effect information about miconazole topical. Some dosage forms listed on this page may not apply to the brand name M-Zole 3.

Applies to miconazole topical: topical cream, topical gel/jelly, topical kit, topical ointment, topical powder, topical solution, topical spray, topical tablet effervescent, topical tincture.

Serious side effects of M-Zole 3

Along with its needed effects, miconazole topical (the active ingredient contained in M-Zole 3) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking miconazole topical:

For Healthcare Professionals

Applies to miconazole topical: compounding powder, topical cream, topical gel, topical liquid, topical lotion, topical ointment, topical powder, topical spray, topical tincture, vaginal cream, vaginal cream with applicator, vaginal kit, vaginal suppository, vaginal tampon.


Local side effects have been reported frequently with topical miconazole therapy. When administered intravaginally or topically, itching, burning and rash have been reported. Contact dermatitis, confirmed by patch testing, has been reported.[Ref]

Nervous system

Nervous system side effects have rarely included headache.[Ref]


Genitourinary side effects have included cramping, pain, and bleeding with the intravaginal use of miconazole.[Ref]

Frequently asked questions


1. Perret CM, Happle R (1988) "Contact allergy to miconazole." Contact Dermatitis, 19, p. 75

2. Baes H (1991) "Contact sensitivity to miconazole with ortho-chloro cross-sensitivity to other imidazoles." Contact Dermatitis, 24, p. 89-93

3. Wade TR, Jones HE, Artis WA (1979) "Irritant and allergic reactions to topically applied Micatin cream." Contact Dermatitis, 5, p. 168-70

4. Raulin C, Frosch PJ (1988) "Contact allergy to imidazole antimycotics." Contact Dermatitis, 18, p. 76-80

5. "Product Information. Monistat 7 (miconazole topical)." Ortho McNeil Pharmaceutical

6. Tanenbaum L, Anderson C, Rosenberg MJ, Akers W (1984) "1% sulconazole cream v 2% miconazole cream in the treatment of tinea versicolor. A double-blind, multicenter study." Arch Dermatol, 120, p. 216-9

7. (1974) "Miconazole--a new topical antifungal drug." Med Lett Drugs Ther, 16, p. 97-8

8. Fernandez L, Maquiera E, Rodriguez F, Picans I, Duque S (1996) "Systemic contact dermatitis from miconazole." Contact Dermatitis, 34, p. 217

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.