Lorcet Side Effects
Generic name: acetaminophen / hydrocodone
Medically reviewed by Drugs.com. Last updated on Jun 30, 2023.
Note: This document provides detailed information about Lorcet Side Effects associated with acetaminophen / hydrocodone. Some dosage forms listed on this page may not apply specifically to the brand name Lorcet.
Applies to acetaminophen / hydrocodone: oral elixir, oral solution, oral tablet.
Important warnings
This medicine can cause some serious health issues
Serious side effects of Lorcet
Along with its needed effects, acetaminophen / hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone:
More common
- dizziness
- lightheadedness
Incidence not known
- agitation
- back, leg, or stomach pains
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- blood in vomit
- bluish lips or skin
- chills
- choking
- confusion
- cough
- dark urine
- darkening of the skin
- decrease in the frequency of urination
- decrease in urine volume
- diarrhea
- difficult or trouble breathing
- difficulty in passing urine (dribbling)
- difficulty with swallowing
- fainting
- fast heartbeat
- fever
- fever with or without chills
- general body swelling
- general feeling of tiredness or weakness
- headache
- hoarseness
- irregular, fast or slow, or shallow breathing
- joint or muscle pain
- light-colored stools
- loss of appetite
- lower back or side pain
- mental depression
- nausea
- nosebleeds
- not breathing
- overactive reflexes
- painful or difficult urination
- pale or blue lips, fingernails, or skin
- pinpoint red spots on the skin
- poor coordination
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red irritated eyes
- red skin lesions, often with a purple center
- restlessness
- severe or continuing stomach pain
- shivering
- skin rash, hives, or itching
- sore throat
- sore tongue
- sores, ulcers, or white spots on the lips or in the mouth
- sweating
- talking or acting with excitement you cannot control
- tightness in the chest
- trembling or shaking
- twitching
- unable to speak
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- vomiting
- yellow eyes and skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:
Symptoms of overdose
- bloody or cloudy urine
- change in consciousness
- chest pain or discomfort
- cold and clammy skin
- coughing that sometimes produces a pink frothy sputum
- decreased awareness or responsiveness
- difficult or trouble breathing
- extreme drowsiness
- general feeling of discomfort or illness
- increased sweating
- irregular, fast or slow, or shallow breathing
- irregular heartbeat
- lightheadedness, dizziness, or fainting
- loss of consciousness
- no blood pressure or pulse
- no muscle tone or movement
- not breathing
- pale or blue lips, fingernails, or skin
- severe sleepiness
- slow or irregular heartbeat
- stopping of heart
- sudden decrease in the amount of urine
- swelling in the legs and ankles
- unpleasant breath odor
Other side effects of Lorcet
Some side effects of acetaminophen / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- drowsiness
- relaxed and calm feeling
- sleepiness
Incidence not known
- belching
- changes in mood
- difficulty having a bowel movement
- fear or nervousness
- feeling of indigestion
- hearing loss
- impaired hearing
- pain in the chest below the breastbone
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
For healthcare professionals
Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral tablet.
General
The most commonly reported adverse reactions include light-headedness, dizziness, sedation, nausea and vomiting.[Ref]
Nervous system
Hydrocodone-acetaminophen:
- Frequency not reported: Dizziness, lightheadedness, mental and physical performance impairment, lethargy, sedation, somnolence progressing to stupor or coma
Opioids:
- Frequency not reported: Serotonin syndrome[Ref]
Cases of serotonin syndrome have been reported during concomitant use of opioids with serotonergic drugs.[Ref]
Cardiovascular
- Frequency not reported: Bradycardia, cardiac arrest, circulatory collapse, hypotension
Hepatic
- Frequency not reported: Hepatic necrosis, hepatitis[Ref]
Gastrointestinal
- Frequency not reported: Abdominal pain, constipation, gastric distress, heartburn, nausea, peptic ulcer, vomiting, occult blood loss[Ref]
Dermatologic
- Frequency not reported: Skin rash, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic reactions, cold and clammy skin, diaphoresis[Ref]
Renal
- Frequency not reported: Renal toxicity, renal tubular necrosis[Ref]
Hematologic
- Frequency not reported: Agranulocytosis, hemolytic anemia, iron deficiency anemia, prolonged bleeding time, thrombocytopenia[Ref]
Hypersensitivity
- Frequency not reported: Allergic reactions, anaphylaxis[Ref]
Respiratory
- Frequency not reported: Acute airway obstruction, apnea, dose-related respiratory depression, shortness of breath[Ref]
Metabolic
- Frequency not reported: Hypoglycemic coma
Genitourinary
- Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention[Ref]
Endocrine
Opioids:
- Frequency not reported: Androgen deficiency, adrenal insufficiency
Other
- Frequency not reported: Hearing impairment or permanent loss[Ref]
Cases of hearing impairment or permanent loss have been reported predominantly in patients with chronic overdose.[Ref]
Musculoskeletal
- Frequency not reported: Skeletal muscle flaccidity
Psychiatric
- Frequency not reported: Anxiety, euphoria, fear, mood changes, psychological dependence, dysphoria
References
1. Turturro MA, Paris PM, Yealy DM, Menegazzi JJ (1991) "Hydrocodone versus codeine in acute musculoskeletal pain." Ann Emerg Med, 20, p. 1100-3
2. (2017) "Product Information. Norco (acetaminophen-hydrocodone)." Allergan Inc
3. (2017) "Product Information. Lortab (acetaminophen-hydrocodone)." Akorn Inc
4. (2017) "Product Information. Acetaminophen-Hydrocodone Bitartrate (acetaminophen-hydrocodone)." Mikart Inc
5. Morrison AB (1979) "Toxicity and abuse of hydrocodone bitartrate." Can Med Assoc J, 120, p. 1338
6. Morrow PL, Faris EC (1987) "Death associated with inadvertent hydrocodone overdose in a child with a respiratory tract infection." Am J Forensic Med Pathol, 8, p. 60-3
7. Fricke J, Halladay SC, Bynum L, Francisco CA (1993) "Pain relief after dental impaction surgery using ketorolac, hydrocodone plus acetaminophen, or placebo." Clin Ther, 15, p. 500-9
8. Sackner MA (1984) "Effects of hydrocodone bitartrate on breathing pattern of patients with chronic obstructive pulmonary disease and restrictive lung disease." Mt Sinai J Med, 51, p. 222-6
9. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB (1986) "Acetaminophen hepatotoxicity in alcoholics." Ann Intern Med, 104, p. 399-404
10. Jackson CH, MacDonald NC, Cornett JW (1984) "Acetaminophen: a practical pharmacologic overview." Can Med Assoc J, 131, p. 25-37
11. Black M (1984) "Acetaminophen hepatotoxicity." Annu Rev Med, 35, p. 577-93
12. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA (1985) "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." Arch Intern Med, 145, p. 2019-23
13. O'Dell JR, Zetterman RK, Burnett DA (1986) "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." JAMA, 255, p. 2636-7
14. Minton NA, Henry JA, Frankel RJ (1988) "Fatal paracetamol poisoning in an epileptic." Hum Toxicol, 7, p. 33-4
15. Keaton MR (1988) "Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion." South Med J, 81, p. 1163-6
16. Shriner K, Goetz MB (1992) "Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med, 93, p. 94-6
17. Wong V, Daly M, Boon A, Heatley V (1993) "Paracetamol and acute biliary pain with cholestasis." Lancet, 342, p. 869
18. Csete M, Sullivan JB (1993) "Vicodin-induced fulminant hepatic failure." Anesthesiology, 79, p. 857-60
19. Thomas RH, Munro DD (1986) "Fixed drug eruption due to paracetamol." Br J Dermatol, 115, p. 357-9
20. Guin JD, Haynie LS, Jackson D, Baker GF (1987) "Wandering fixed drug eruption: a mucocutaneous reaction to acetaminophen." J Am Acad Dermatol, 17, p. 399-402
21. Gabriel R, Caldwell J, Hartley RB (1982) "Acute tubular necrosis, caused by therapeutic doses of paracetamol?" Clin Nephrol, 18, p. 269-71
22. Segasothy M, Suleiman AB, Puvaneswary M, Rohana A (1988) "Paracetamol: a cause for analgesic nephropathy and end-stage renal disease." Nephron, 50, p. 50-4
23. Shoenfeld Y, Shaklai M, Livni E, Pinkhas J (1980) "Thrombocytopenia from acetaminophen." N Engl J Med, 303, p. 47
24. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH (2007) "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Blood, 109, p. 3608-9
25. Settipane RA, Stevenson DD (1989) "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma." J Allergy Clin Immunol, 84, p. 26-33
26. Van Diem L, Grilliat JP (1990) "Anaphylactic shock induced by paracetamol." Eur J Clin Pharmacol, 38, p. 389-90
27. Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K (1993) "Acetaminophen-induced eosinophilic pneumonia." Chest, 104, p. 291-2
28. Cohen J, Tattersfield H, Lloyd D, Cantopher T (1990) "A request for a strong analgesic." Practitioner, 234, p. 691-4
More about Lorcet (acetaminophen / hydrocodone)
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Further information
Lorcet side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.