Locholest Side Effects
Generic Name: cholestyramine
Note: This page contains information about the side effects of cholestyramine. Some of the dosage forms included on this document may not apply to the brand name Locholest.
For the Consumer
Applies to cholestyramine: oral powder for suspension, oral tablet
In some animal studies, cholestyramine (the active ingredient contained in Locholest) was found to cause tumors. It is not known whether cholestyramine causes tumors in humans.
In addition to its needed effects, some unwanted effects may be caused by cholestyramine. In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking cholestyramine:Rare
- Black, tarry stools
- stomach pain (severe) with nausea and vomiting
If any of the following side effects occur while taking cholestyramine, check with your doctor or nurse as soon as possible:More common:
- Loss of weight (sudden)
Minor Side Effects
Some of the side effects that can occur with cholestyramine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common:
- Heartburn or indigestion
- nausea or vomiting
- stomach pain
For Healthcare Professionals
Applies to cholestyramine: compounding powder, oral powder for reconstitution
The most frequently reported side effect is constipation.[Ref]
Intestinal obstruction occurred rarely and 2 deaths in pediatric patients were reported.[Ref]
Very common (10% or more): Constipation
Uncommon (0.1% to 1%): Tongue irritation, irritation of perianal area, abdominal discomfort/pain/distention, flatulence, nausea, vomiting, diarrhea, heartburn, dyspepsia, steatorrhea
Rare (less than 0.1%): Intestinal obstruction
Frequency not reported: Rectal bleeding, black stools, hemorrhoidal bleeding, bleeding from known duodenal ulcer, dysphagia, hiccoughs, ulcer attack, sour taste, pancreatitis, rectal pain, diverticulitis, eructation, dental bleeding, dental caries, calcification of gallbladder, tooth discoloration, erosion of tooth enamel[Ref]
Frequency not reported: Claudication, angina, arteritis, thrombophlebitis, myocardial infarction, myocardial ischemia, postprandial angina increased[Ref]
Common (1% to 10%): Osteoporosis
Frequency not reported: Backache, arthritis, muscle/joint pain[Ref]
Uncommon (0.1% to 1%): Bleeding
Frequency not reported: Prothrombin time increased, prothrombin time decreased, anemia, hypoprothrombinemia[Ref]
Uncommon (0.1% to 1%): Anorexia, hyperchloremic acidosis, Vitamin A deficiency, Vitamin K deficiency[Ref]
Uncommon (0.1% to 1%): Rash, skin irritation
Frequency not reported: Ecchymosis, xanthoma of hands/fingers, urticaria[Ref]
Frequency not reported: Liver function test abnormal[Ref]
Frequency not reported: Headache, paresthesia, syncope, dizziness, drowsiness, femoral nerve pain[Ref]
Frequency not reported: Vertigo, weight loss, weight gain, glands swollen, edema, chest pain, tinnitus[Ref]
Frequency not reported: Arcus juvenilis, uveitis, night blindness[Ref]
Frequency not reported: Hematuria, dysuria, burnt odor to urine, diuresis[Ref]
Frequency not reported: Asthma, wheezing, shortness of breath[Ref]
Frequency not reported: Libido increased[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Cholestyramine Light (cholestyramine)." Sandoz Laboratories, Eon Division, Lake Success, NY.
Not all side effects for Locholest may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about Locholest (cholestyramine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: bile acid sequestrants
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