Lixisenatide Side Effects
Medically reviewed by Drugs.com. Last updated on Apr 3, 2021.
For the Consumer
Applies to lixisenatide: subcutaneous solution
Side effects requiring immediate medical attention
Along with its needed effects, lixisenatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lixisenatide:
- bluish or pale skin
- blurred vision
- cold sweats
- darkened urine
- difficulty swallowing
- fast heartbeat
- hives, itching, redness, skin rash
- increased hunger
- loss of appetite
- pains in the stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- slurred speech
- tightness in the chest
- troubled breathing
- unusual tiredness or weakness
- yellow eyes or skin
Incidence not known
- decreased urine output
- muscle twitching
- rapid weight gain
- swelling of the face, ankles, or hands
Get emergency help immediately if any of the following symptoms of overdose occur while taking lixisenatide:
Symptoms of overdose
- loss of appetite
- nausea or vomiting
- stomach pain, fullness, or discomfort
- passing of gas
Side effects not requiring immediate medical attention
Some side effects of lixisenatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Acid or sour stomach
- bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- pressure in the stomach
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to lixisenatide: subcutaneous kit, subcutaneous solution
Very common (10% or more): Nausea (up to 26.5%), vomiting (up to 10.5%)
Gastrointestinal adverse reactions including nausea and vomiting were responsible for discontinuation of treatment in 4.3% of patients. During clinical trials, the severity of gastrointestinal adverse reactions were graded as mild, moderate or severe in 64.2%, 32.3%, and 3.5% of cases, respectively. The majority of reactions occurred during the first 3 weeks of treatment.
During clinical trials, 21 cases of pancreatitis were reported including acute pancreatitis (n=3), pancreatitis (n=12), chronic pancreatitis (n=5), and edematous pancreatitis (n=1). Of these cases, some had risk factors such as a history of cholelithiasis or alcohol abuse. Fourteen cases of pancreatitis were reported in the comparator-treated.[Ref]
Pooled analysis of drug-treated patients has found that almost 70% were antibody positive at 24 weeks. Of the antibody positive patients, those with the highest antibody concentrations (greater than 100 nmol/L) had attenuated glycemic responses. Additionally, a higher incidence of allergic reactions and injection site reactions occurred in antibody positive patients.[Ref]
Very common (10% or more): Development of anti-lixisenatide antibodies (69.8%)[Ref]
Very common (10% or more): Hypoglycemia (in combination with a sulfonylurea and/or a basal insulin)
Very common (10% or more): Headache
Common (1% to 10%): Dizziness, somnolence[Ref]
Common (1% to 10%): Palpitations
Common (1% to 10%): Viral infection[Ref]
Frequently asked questions
- Soliqua vs Lantus: What’s the difference between them?
- What is the difference between Soliqua and Xultophy?
- How often do you need to inject Adlyxin?
More about lixisenatide
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- Drug class: incretin mimetics
- Other brands
Related treatment guides
1. "Product Information. Adlyxin (lixisenatide)." sanofi-aventis, Bridgewater, NJ.
2. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects may not be reported. You may report them to the FDA.