Liptruzet Side Effects

Generic Name: atorvastatin / ezetimibe

Note: This page contains information about the side effects of atorvastatin / ezetimibe. Some of the dosage forms included on this document may not apply to the brand name Liptruzet.

For the Consumer

Applies to atorvastatin / ezetimibe: oral tablet

In addition to its needed effects, some unwanted effects may be caused by atorvastatin / ezetimibe. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking atorvastatin / ezetimibe:

• Abdominal or stomach pain
• confusion
• difficult breathing
• difficulty with moving
• irregular heartbeat
• muscle, joint, or bone pain
• muscle stiffness
• muscle weakness
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• weakness or heaviness of the legs

• Black, tarry stools
• blistering, peeling, or loosening of the skin
• blood in the urine or stools
• chills
• dark-colored urine
• diarrhea
• fever
• gaseous abdominal or stomach pain
• general tiredness and weakness
• hives, welts, or skin rash
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• severe nausea or vomiting
• sores, ulcers, or white spots in the mouth or on the lips
• swelling of the eyes, face, or inside of the nose
• unsteadiness or awkwardness
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes and skin

Minor Side Effects

Some of the side effects that can occur with atorvastatin / ezetimibe may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Cough
• dizziness
• feeling of warmth
• pain or tenderness around the eyes and cheekbones
• redness of the face, neck, arms, and occasionally, upper chest
• stuffy or runny nose
• sudden sweating
• tightness in the chest

• Being forgetful
• bloating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chills
• constipation
• discouragement
• fast heartbeat
• feeling sad or empty
• irritability
• lack of appetite
• loss of interest or pleasure
• loss of memory
• pains in the stomach, side, or abdomen, possibly radiating to the back
• tiredness
• trouble concentrating
• trouble sleeping

For Healthcare Professionals

Applies to atorvastatin / ezetimibe: oral tablet

Dermatologic

Postmarketing reports: Angioedema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), rash, urticaria^[Ref]

Endocrine

Common (1% to 10%): Hot flushes (2%)^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea (4.1 to 6.8%), abdominal pain (3%), nausea (3 to 4%), dyspepsia (4.7%)^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection (5.7%)^[Ref]

Hematologic

Postmarketing reports: Thrombocytopenia, elevated creatine phosphokinase^[Ref]

Hepatic

Common (1% to 10%): ALT increased (5%), AST increased (4%)
Postmarketing reports: Hepatitis, cholelithiasis, cholecystitis, fatal and nonfatal hepatic failure^[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis, hypersensitivity reactions^[Ref]

Immunologic

Common (1% to 10%): Influenza (2%)^[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia (2%)^[Ref]

Musculoskeletal

Common (1% to 10%): Musculoskeletal pain (3.8 to 4%), arthralgia (3 to 6.9%), pain in extremity (2.7 to 6%), myalgia (3.5%), muscle spasms (3%), muscle weakness (2%)
Postmarketing reports: Myopathy/rhabdomyolysis, necrotizing myopathy (rarely), injury, poisoning and procedural complication, tendon rupture^[Ref]

Nervous system

Common (1% to 10%): Dizziness (2 to 6%), insomnia (3%), fatigue (2.4%)
Postmarketing reports: Headache, paresthesia, peripheral neuropathy, amnesia, memory impairment, confusion, depression^[Ref]

Respiratory

Common (1% to 10%): Coughing (2 to 3%), bronchitis (2%), sinusitis (2 to 2.8%), upper respiratory tract infection (4.3%), nasopharyngitis (up to 8.3%), pharyngolaryngeal pain (up to 2.3%)^[Ref]

Not all side effects for Liptruzet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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