Skip to Content

Lincocin Side Effects

Generic name: lincomycin

Medically reviewed by Drugs.com. Last updated on Oct 14, 2020.

Note: This document contains side effect information about lincomycin. Some of the dosage forms listed on this page may not apply to the brand name Lincocin.

For the Consumer

Applies to lincomycin: injection solution

Warning

Injection route (Solution)

Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including lincomycin, and may range in severity from mild diarrhea to fatal colitis. Therefore, lincomycin therapy should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C difficile may need to be discontinued. Appropriate supportive therapy, such as fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation should be instituted as clinically indicated.

Side effects requiring immediate medical attention

Along with its needed effects, lincomycin (the active ingredient contained in Lincocin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lincomycin:

Incidence not known

  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • blistering, peeling, or loosening of the skin
  • blurred vision
  • chills
  • clay-colored stools
  • confusion
  • cough
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • fever
  • headache
  • hives, itching, or rash
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • severe abdominal or stomach cramps and pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • tightness in the chest
  • ulcers, sores, or white spots in the mouth
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of lincomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Abdominal or stomach discomfort
  • continuing ringing or buzzing or other unexplained noise in the ears
  • feeling of constant movement of self or surroundings
  • hearing loss
  • pain, redness, or hard lumps at the injection site
  • redness, swelling, or soreness of the tongue
  • sensation of spinning
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule

Gastrointestinal

The onset of pseudomembranous colitis symptoms has been reported during and after antibacterial therapy.

Esophagitis was reported with oral preparations.[Ref]

Frequency not reported: Glossitis, stomatitis, nausea, vomiting, abdominal distress, persistent diarrhea, enterocolitis, antibacterial-associated diarrhea and colitis, pruritus ani, pseudomembranous colitis, Clostridium difficile associated diarrhea, esophagitis[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (such as angioneurotic edema, serum sickness, anaphylaxis); face, ears, and neck swelling[Ref]

Some hypersensitivity reactions occurred in penicillin-sensitive patients.

A 19-year-old male patient, who had received 2 previous IM injections of lincomycin at the age of 17 years and 1 IM injection 2 weeks prior, reported that a few minutes after his fourth IM injection he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone IM followed by oral prednisone with an antihistamine.[Ref]

Dermatologic

Rare (less than 0.1%): Exfoliative and vesiculobullous dermatitis

Frequency not reported: Skin rashes, urticaria, pruritus, erythema multiforme (some resembling Stevens-Johnson syndrome)[Ref]

Hematologic

Rare (less than 0.1%): Aplastic anemia, pancytopenia

Frequency not reported: Neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura[Ref]

Cardiovascular

Cases of hypotension after parenteral administration have been reported, especially after too rapid IV administration. Rare cases of cardiopulmonary arrest have been reported after this drug was administered IV too rapidly. In these cases, the affected patients subsequently tolerated slow infusions. A study that looked at multiple large dose administration of this drug found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.[Ref]

Rare (less than 0.1%): Cardiopulmonary arrest

Frequency not reported: Hypotension[Ref]

Hepatic

Frequency not reported: Jaundice, abnormal liver function tests (especially elevated serum transaminase)[Ref]

Renal

Rare (less than 0.1%): Renal dysfunction, azotemia, oliguria[Ref]

Genitourinary

Rare (less than 0.1%): Proteinuria

Frequency not reported: Vaginitis[Ref]

Nervous system

Frequency not reported: Tinnitus, vertigo, neuromuscular blockade, metallic taste in mouth[Ref]

Local

Frequency not reported:

-IM: Pain following injection, local irritation, pain induration, sterile abscess formation

-IV: Thrombophlebitis[Ref]

Ocular

Frequency not reported: Bulbar conjunctival injection

References

1. Novak E, Vitti TG, Panzer JD, Schlagel C, Hearron MS "Antibiotic tolerance and serum levels after intravenous administration of multiple large doses of lincomycin." Clin Pharmacol Ther 12 (1971): 793-7

2. Mickal A, Dildy GA, Miller HJ "Lincomycin in the treatment of cervicitis and vagini in pregnancy." South Med J 59 (1966): 567-70

3. Scott AJ, Nicholson GI "The recognition of pseudomembranous colitis as a clinical entity." Aust N Z J Med 4 (1974): 502-9

4. Bartlett JG "Anti-anaerobic antibacterial agents." Lancet 2 (1982): 478-81

5. Burbige EJ, Milligan FD "Pseudomembranous colitis. Association with antibiotics and therapy with cholestyramine." JAMA 231 (1975): 1157-8

6. "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 591

7. Phillips I "Past and current use of clindamycin and lincomycin." J Antimicrob Chemother 7 Suppl A (1981): 11-8

8. Gibson GE, Rowland R, Hecker R "Diarrhoea and colitis associated with antibiotic treatment." Aust N Z J Med 5 (1975): 340-7

9. Berry DD, Brouhard BH, Box QT "Adverse reactions to parenteral lincomycin." Pediatrics 67 (1981): 389-91

10. Keighley MR, Arabi Y, Matheson D, Alexander-Williams J "Aspects of preventing sepsis in colo-rectal surgery: results of recent clinical trials." J Antimicrob Chemother 4 Suppl C (1978): 33-8

11. "The macrolides and lincomycin." Br Med J 3 (1968): 233-4

12. Burdon DW "Prophylaxis in surgery." J Antimicrob Chemother 7 Suppl A (1981): 19-25

13. Ashton H, Beveridge GW, Stevenson CJ "Lincomycin and clindamycin." Br J Dermatol 83 (1970): 604-6

14. Crapp AR, Powis J, Clark C, Keighley MR, Alexander-Williams J "Letter: Postoperative pseudomembranous colitis." Br Med J 3 (1975): 227

15. Price DJ, O'Grady FW, Shooter RA, Weaver PC "Trial of phenyoxymethylpenicillin, phenethicillin, and lincomycin in treatment of staphylococcal sepsis in a casualty department." Br Med J 2 (1968): 407-9

16. "Lincomycin and clindamycin colitis." Br Med J 4 (1974): 65-6

17. Kinsella PL "Letter: Antibiotic diarrhoea." Br Med J 4 (1975): 580

18. Clark CE, Thompson H, Mcleish AR, Powis SJ, Dorricott NJ, Alexander-Williams J "Pseudomembranous colitis following prophylactic antibiotics in bowel surgery." J Antimicrob Chemother 2 (1976): 167-73

19. "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn, Kalamazoo, MI.

20. Viteri AL, Howard PH, Dyck WP "The spectrum of lincomycin-clindamycin colitis." Gastroenterology 66 (1974): 1137-44

21. Scott AJ, Nicholson GI, Kerr AR "Lincomycin as a cause of pseudomembranous colitis." Lancet 2 (1973): 1232-4

22. Parsons RL, Beavis JP, Salfield JB "Letter: Diarrhoea and colitis associated with antibiotic therapy." Br Med J 4 (1975): 42

23. Pittman FE, Pittman JC, Humphrey CD "Letter: Lincomycin and pseudomembranous colitis." Lancet 1 (1974): 451-2

24. Jaimes EC "Lincocinamides and the incidence of antibiotic-associated colitis." Clin Ther 13 (1991): 270-80

25. Bartlett JG, Sutter VL, Finegold SM "Treatment of anaerobic infections with lincomycin and clindamycin." N Engl J Med 287 (1972): 1006-10

26. Boyd WC, DenBesten L "Subtotal colectomy for refractory pseudomembranous enterocolitis." JAMA 235 (1976): 181

27. McCool D, Miller RR "Treatment of lincomycin-caused diarrhea." JAMA 236 (1976): 1937-8

28. Marks MI, Shapera RM, Brazeau M "Pediatric antimicrobial therapy 3." Can Med Assoc J 109 (1973): 213-4

29. Hamilton-Miller JM "Antimicrobial agents acting against anaerobes." J Antimicrob Chemother 1 (1975): 273-89

30. Venning GR "Identification of adverse reactions to new drugs. II (continued): How were 18 important adverse reactions discovered and with what delays?" Br Med J (Clin Res Ed) 286 (1983): 365-8

31. Liner SR "Adverse reactions to parenteral lincomycin." Pediatrics 68 (1981): 615-6

32. Wilson DH, Cunliffe WJ, Tan SG "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 288-9

33. Munk JF, Collopy BT, Connell JL, et al. "Lincomycin-clindamycin-associated psuedomembranous colitis." Med J Aust 2 (1976): 95-7

34. Robertson MB, Breen KJ, Desmond PV, Mashford ML, McHugh AM "Incidence of antibiotic-related diarrhoea and pseudomembranous colitis: a prospective study of lincomycin, clindamycin and ampicillin." Med J Aust 1 (1977): 243-6

35. Lambert HP "Unwanted effects of antibiotics: some recent additions." J Antimicrob Chemother 1 (1975): 2-4

36. George WL, Sutter VL, Finegold SM "Antimicrobial agent-induced diarrhea--a bacterial disease." J Infect Dis 136 (1977): 822-8

37. Sanders E "Lincomycin versus erythromycin: a choice or an echo." Ann Intern Med 70 (1969): 585-90

38. Kaplan K, Weinstein L "Lincomycin." Pediatr Clin North Am 15 (1968): 131-9

39. Mohr JA, Rhoades ER, Muchmore HG "Actinomycosis treated with lincomycin." JAMA 212 (1970): 2260-2

40. Walker WG "Hypersensitivity reaction in a patient receiving lincomycin." Can Med Assoc J 101 (1969): 130

41. Duncan IB, Jeans B "Lincomycin in hospital practice." Can Med Assoc J 93 (1965): 685-91

42. Raff MJ "Lincomycin: thrombocytopenia?" Ann Intern Med 78 (1973): 779

43. Brown EB, Cunningham CE "Granulocytopenia occurring during the administration of lincomycin." JAMA 194 (1965): 668-70

44. Daubeck JL, Daughety MJ, Petty C "Lincomycin-induced cardiac arrest: a case report and laboratory investigation." Anesth Analg 53 (1974): 563-7

45. Waisbren BA "Lincomycin in larger doses." JAMA 206 (1968): 2118

46. Duignan NM, Andrews J, Williams JD "Pharmacological studies with lincomycin in late pregnancy." Br Med J 3 (1973): 75-8

47. Darrell JH, Uttley AH "Antibiotics in the peri-operative period." Br J Anaesth 48 (1976): 13-9

48. Samuelson RJ, Giesecke AT Jr, Kallus FT, Stanley VF "Lincomycin-curare interaction." Anesth Analg 54 (1975): 103-5

49. Snavely SR, Hodges GR "The neurotoxicity of antibacterial agents." Ann Intern Med 101 (1984): 92-104

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.