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Ixazomib Side Effects

In Summary

Commonly reported side effects of ixazomib include: constipation, diarrhea, macular eruption, maculopapular rash, nausea, peripheral edema, peripheral neuropathy, peripheral sensory neuropathy, skin rash, and vomiting. Other side effects include: hepatic insufficiency. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ixazomib: oral capsule

In addition to its needed effects, some unwanted effects may be caused by ixazomib. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking ixazomib:

More common:
  • Abdominal or stomach pain
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chills
  • cough
  • dark urine
  • diarrhea
  • dizziness
  • fever
  • headache
  • itching or rash
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • nausea
  • numbness, tingling, or pain in the hands or feet
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • redness or discoloration of the skin
  • sore throat
  • tingling of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting of blood
  • yellow eyes or skin
Less common:
  • Bleeding gums
  • blood in the urine or stools
Rare
  • Blistering, peeling, or loosening of the skin
  • bloody nose
  • heavier menstrual periods
  • joint or muscle pain
  • red skin lesions, often with a purple center
  • red, irritated eyes

Minor Side Effects

Some of the side effects that can occur with ixazomib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Back pain
  • blurred vision
  • body aches or pain
  • burning, dry, or itching eyes
  • difficulty having a bowel movement (stool)
  • discharge, excessive tearing
  • ear congestion
  • loss of voice
  • nasal congestion
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sneezing

For Healthcare Professionals

Applies to ixazomib: oral capsule

Cardiovascular

Very common (10% or more): Peripheral edema (18%)[Ref]

Dermatologic

Very common (10% or more): Rash (11%)
Postmarketing reports: Acute febrile neutrophilic dermatosis (Sweet's syndrome), Stevens-Johnson syndrome[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (36%), constipation (25%), nausea (21%)[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (78%), neutropenia (67%), thrombotic thrombocytopenic purpura[Ref]

Hepatic

Frequency not reported: Hepatotoxicity[Ref]

Immunologic

Postmarketing reports: Transverse myelitis[Ref]

Metabolic

Postmarketing reports: Tumor lysis syndrome[Ref]

Musculoskeletal

Very common (10% or more): Back pain (16%)[Ref]

Nervous system

Frequency not reported: Peripheral neuropathy (21%)
Postmarketing reports: Posterior reversible encephalopathy syndrome[Ref]

Ocular

Common (1% to 10%): Blurred vision, dry eye, conjunctivitis[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (14%)[Ref]

References

1. "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Not all side effects for ixazomib may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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