Ixazomib Side Effects
Medically reviewed by Drugs.com. Last updated on Dec 8, 2020.
Commonly reported side effects of ixazomib include: constipation, diarrhea, macular eruption, maculopapular rash, nausea, peripheral edema, peripheral neuropathy, peripheral sensory neuropathy, skin rash, and vomiting. Other side effects include: hepatic insufficiency. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to ixazomib: oral capsule
Side effects requiring immediate medical attention
Along with its needed effects, ixazomib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ixazomib:
- Black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- burning, numbness, tingling, or painful sensations
- dark urine
- itching or rash
- light-colored stools
- loss of appetite
- lower back or side pain
- numbness, tingling, or pain in the hands or feet
- painful or difficult urination
- pale skin
- rapid weight gain
- rash with flat lesions or small raised lesions on the skin
- redness or discoloration of the skin
- sore throat
- stomach pain
- tingling of the hands or feet
- ulcers, sores, or white spots in the mouth
- unpleasant breath odor
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting of blood
- weakness in the arms, hands, legs, or feet
- yellow eyes or skin
- Bleeding gums
- blood in the urine or stools
- pinpoint red spots on the skin
- Blistering, peeling, or loosening of the skin
- bloody nose
- heavier menstrual periods
- joint or muscle pain
- red skin lesions, often with a purple center
- red, irritated eyes
Side effects not requiring immediate medical attention
Some side effects of ixazomib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Back pain
- blurred vision
- body aches or pain
- burning, dry, or itching eyes
- difficulty having a bowel movement (stool)
- discharge, excessive tearing
- ear congestion
- loss of voice
- nasal congestion
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
For Healthcare Professionals
Applies to ixazomib: oral capsule
Very common (10% or more): Rash (11%)
Rare (less than 0.1%): Thrombotic microangiopathy[Ref]
Frequency not reported: Hepatotoxicity[Ref]
Very common (10% or more): Back pain (16%)[Ref]
Frequency not reported: Peripheral neuropathy (21%)
Frequently asked questions
- Ninlaro vs Velcade, which is better?
- Is Ninlaro (ixazomib) a chemotherapy drug? How does it work?
- Does Ninlaro cause shingles (herpes zoster)?
- How effective is Ninlaro (ixazomib)?
More about ixazomib
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 3 Reviews
- Drug class: proteasome inhibitors
- Other brands
Related treatment guides
1. "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America, Lincolnshire, IL.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Some side effects may not be reported. You may report them to the FDA.