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Ixazomib Side Effects

Medically reviewed by Last updated on May 22, 2022.


Commonly reported side effects of ixazomib include: constipation, diarrhea, macular eruption, maculopapular rash, nausea, peripheral edema, peripheral neuropathy, peripheral sensory neuropathy, skin rash, and vomiting. Other side effects include: hepatic insufficiency. Continue reading for a comprehensive list of adverse effects.

Applies to ixazomib: oral capsule.

Serious side effects of Ixazomib

Along with its needed effects, ixazomib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ixazomib:

More common

  • Black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • dark urine
  • diarrhea
  • dizziness
  • fever
  • headache
  • itching or rash
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • nausea
  • numbness, tingling, or pain in the hands or feet
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • redness or discoloration of the skin
  • sore throat
  • stomach pain
  • tingling of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unpleasant breath odor
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting of blood
  • weakness in the arms, hands, legs, or feet
  • yellow eyes or skin

Less common

  • Bleeding gums
  • blood in the urine or stools
  • pinpoint red spots on the skin


  • Blistering, peeling, or loosening of the skin
  • bloody nose
  • heavier menstrual periods
  • joint or muscle pain
  • red skin lesions, often with a purple center
  • red, irritated eyes

Other side effects of Ixazomib

Some side effects of ixazomib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • blurred vision
  • body aches or pain
  • burning, dry, or itching eyes
  • difficulty having a bowel movement (stool)
  • discharge, excessive tearing
  • ear congestion
  • loss of voice
  • nasal congestion
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sneezing

For Healthcare Professionals

Applies to ixazomib: oral capsule.


Very common (10% or more): Peripheral edema (18%)[Ref]


Very common (10% or more): Rash (11%)

Postmarketing reports: Acute febrile neutrophilic dermatosis (Sweet's syndrome), Stevens-Johnson syndrome[Ref]


Very common (10% or more): Diarrhea (36%), constipation (25%), nausea (21%)[Ref]


Very common (10% or more): Thrombocytopenia (78%), neutropenia (67%), thrombotic thrombocytopenic purpura

Rare (less than 0.1%): Thrombotic microangiopathy[Ref]


Frequency not reported: Hepatotoxicity[Ref]


Postmarketing reports: Transverse myelitis[Ref]


Postmarketing reports: Tumor lysis syndrome[Ref]


Very common (10% or more): Back pain (16%)[Ref]

Nervous system

Frequency not reported: Peripheral neuropathy (21%)

Postmarketing reports: Posterior reversible encephalopathy syndrome[Ref]


Common (1% to 10%): Blurred vision, dry eye, conjunctivitis[Ref]


Very common (10% or more): Upper respiratory tract infection (14%)[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.