Hyzaar Side Effects

Generic name: hydrochlorothiazide / losartan

Medically reviewed by Drugs.com. Last updated on May 12, 2024.

Note: This document provides detailed information about Hyzaar Side Effects associated with hydrochlorothiazide / losartan. Some dosage forms listed on this page may not apply specifically to the brand name Hyzaar.

Applies to hydrochlorothiazide / losartan: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need to stop using this medicine.

This medicine may cause dizziness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you become sick while taking this medicine, especially if you have severe or continuing nausea or vomiting, or diarrhea that does not stop. These conditions may cause you to lose too much water and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Check with your doctor immediately if blurred vision, difficulty reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor to check your eyes.

This medicine may affect blood sugar levels. Diabetic patients may notice a change in the results of blood or urine glucose tests. Talk to your doctor if you have any questions.

Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

Drinking alcohol or taking narcotic pain relievers or sleeping pills with this medicine may intensify feeling lightheaded, dizzy, or faint. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Common side effects of Hyzaar

Some side effects of hydrochlorothiazide / losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Hyzaar

Along with its needed effects, hydrochlorothiazide/losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / losartan:

For healthcare professionals

Applies to hydrochlorothiazide / losartan: oral tablet.

General adverse events

The most common adverse reaction was dizziness.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache

Losartan:

• Frequency not reported: Syncope, cerebrovascular accident, ataxia, hypesthesia, memory impairment, migraine, paresthesia, peripheral neuropathy, somnolence, vertigo, tremor, taste perversion, tinnitus^[Ref]

Respiratory

• Common (1% to 10%): Cough, sinusitis, upper respiratory infection, bronchitis, pharyngitis

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Losartan:

• Frequency not reported: Dyspnea, epistaxis, nasal congestion, pharyngeal discomfort, respiratory congestion, rhinitis, sinus disorder
• Postmarketing reports: Dry cough^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, diarrhea, nausea

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation

Losartan:

• Frequency not reported: Constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitation, essential hypertension
• Uncommon (0.1% to 1%): Hypotension

Hydrochlorothiazide:

• Frequency not reported: Vasculitis

Losartan:

• Frequency not reported: Angina pectoris, arrhythmias, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, hypotension, myocardial infarction, second degree atrioventricular block, flushing
• Postmarketing reports: Vasculitis^[Ref]

Other

• Common (1% to 10%): Edema/swelling, asthenia/fatigue

Hydrochlorothiazide:

• Frequency not reported: Weakness, fever

Losartan:

• Frequency not reported: Chest pain, facial edema, fever, orthostatic effects, malaise^[Ref]

Dermatologic

• Common (1% to 10%): Rash

Hydrochlorothiazide:

• Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis

Losartan:

• Common (1% to 10%): Rash
• Frequency not reported: Angioedema, superficial peeling of palms, alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, pruritus, sweating, urticaria
• Postmarketing reports: Erythroderma^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm

Losartan:

• Frequency not reported: Arm pain, arthralgia, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness, musculoskeletal pain, myalgia, shoulder pain, stiffness
• Postmarketing reports: Rhabdomyolysis^[Ref]

Renal

• Uncommon (0.1% to 1%): Serum creatinine increased greater than 5 mg/dL, BUN increased

Hydrochlorothiazide:

• Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Losartan:

• Common (1% to 10%): Serum creatinine increased greater than 5 mg/dL^[Ref]

Hepatic

• Frequency not reported: Liver enzymes elevated, serum bilirubin elevated
• Postmarketing reports: Hepatitis

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice

Losartan:

• Postmarketing reports: Hepatitis^[Ref]

Hematologic

• Frequency not reported: Hemoglobin decreased, hematocrit decreased

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Losartan:

• Frequency not reported: Hemolysis, anemia^[Ref]

Metabolic

• Postmarketing reports: Hyperkalemia

Hydrochlorothiazide:

• Frequency not reported: Hyperglycemia, hyperuricemia

Losartan:

• Frequency not reported: Anorexia, gout
• Postmarketing reports: Hyperkalemia, hyponatremia^[Ref]

Ocular

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia

Losartan:

• Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased^[Ref]

Psychiatric

Hydrochlorothiazide:

• Frequency not reported: Restlessness

Losartan:

• Frequency not reported: Anxiety, anxiety disorder, confusion, dream abnormality, depression, insomnia, libido decreased, nervousness, panic disorder, sleep disorder^[Ref]

Genitourinary

Hydrochlorothiazide:

• Frequency not reported: Glycosuria

Losartan:

• Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection^[Ref]

Immunologic

Losartan:

• Postmarketing reports: Anaphylactic reactions^[Ref]

See also:

Further information

Hyzaar side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer