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Hyzaar Side Effects

Generic Name: hydrochlorothiazide / losartan

Note: This document contains side effect information about hydrochlorothiazide / losartan. Some of the dosage forms listed on this page may not apply to the brand name Hyzaar.

For the Consumer

Applies to hydrochlorothiazide / losartan: oral tablet

Along with its needed effects, hydrochlorothiazide / losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / losartan:

Rare
  • Black, tarry stools
  • blood in the urine or stools
  • cough or hoarseness accompanied by chills or fever, lower back or side pain, or painful or difficult urination
  • fainting
  • pinpoint red spots on the skin
  • pounding heartbeat
  • severe stomach pain, nausea, and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • unusual bleeding or bruising
Incidence not known
  • Coma
  • confusion
  • dark-colored urine
  • decreased urine output
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • increased thirst
  • irritability
  • large, flat, blue, or purplish patches in the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • muscle cramps or pain
  • muscle spasms
  • muscle stiffness
  • muscle twitching
  • nausea or vomiting
  • painful knees and ankles
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • restlessness
  • seizures
  • shortness of breath
  • swelling of the face, ankles, or hands
  • upper right abdominal or stomach pain
  • unusual tiredness or weakness
  • weak or irregular heartbeat
  • yellow eyes and skin

Some side effects of hydrochlorothiazide / losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cold or flu-like symptoms
  • dizziness
  • headache
  • increased sensitivity of the skin to sunlight
  • sore throat
  • stomach pain
Rare
  • Dry cough
  • sinus problems

For Healthcare Professionals

Applies to hydrochlorothiazide / losartan: oral tablet

General

The most common adverse reaction was dizziness.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Losartan:
Frequency not reported: Syncope, cerebrovascular accident, ataxia, hypesthesia, memory impairment, migraine, paresthesia, peripheral neuropathy, somnolence, vertigo, tremor, taste perversion, tinnitus[Ref]

Respiratory

Common (1% to 10%): Cough, sinusitis, upper respiratory infection, bronchitis, pharyngitis

Hydrochlorothiazide:
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Losartan:
Frequency not reported: Dyspnea, epistaxis, nasal congestion, pharyngeal discomfort, respiratory congestion, rhinitis, sinus disorder
Postmarketing reports: Dry cough[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, diarrhea, nausea

Hydrochlorothiazide:
Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation

Losartan:
Frequency not reported: Constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting[Ref]

Cardiovascular

Common (1% to 10%): Palpitation, essential hypertension
Uncommon (0.1% to 1%): Hypotension

Hydrochlorothiazide:
Frequency not reported: Vasculitis

Losartan:
Frequency not reported: Angina pectoris, arrhythmias, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, hypotension, myocardial infarction, second degree atrioventricular block, flushing
Postmarketing reports: Vasculitis[Ref]

Other

Common (1% to 10%): Edema/swelling, asthenia/fatigue

Hydrochlorothiazide:
Frequency not reported: Weakness, fever

Losartan:
Frequency not reported: Chest pain, facial edema, fever, orthostatic effects, malaise[Ref]

Dermatologic

Common (1% to 10%): Rash

Hydrochlorothiazide:
Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis

Losartan:
Common (1% to 10%): Rash
Frequency not reported: Angioedema, superficial peeling of palms, alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, pruritus, sweating, urticaria
Postmarketing reports: Erythroderma[Ref]

Musculoskeletal

Common (1% to 10%): Back pain

Hydrochlorothiazide:
Frequency not reported: Muscle spasm

Losartan:
Frequency not reported: Arm pain, arthralgia, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness, musculoskeletal pain, myalgia, shoulder pain, stiffness
Postmarketing reports: Rhabdomyolysis[Ref]

Renal

Uncommon (0.1% to 1%): Serum creatinine increased greater than 5 mg/dL, BUN increased

Hydrochlorothiazide:
Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Losartan:
Common (1% to 10%): Serum creatinine increased greater than 5 mg/dL[Ref]

Hepatic

Frequency not reported: Liver enzymes elevated, serum bilirubin elevated
Postmarketing reports: Hepatitis

Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice

Losartan:
Postmarketing reports: Hepatitis[Ref]

Hematologic

Frequency not reported: Hemoglobin decreased, hematocrit decreased

Hydrochlorothiazide:
Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Losartan:
Frequency not reported: Hemolysis, anemia[Ref]

Metabolic

Postmarketing reports: Hyperkalemia

Hydrochlorothiazide:
Frequency not reported: Hyperglycemia, hyperuricemia

Losartan:
Frequency not reported: Anorexia, gout
Postmarketing reports: Hyperkalemia, hyponatremia[Ref]

Ocular

Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, xanthopsia

Losartan:
Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased[Ref]

Psychiatric

Hydrochlorothiazide:
Frequency not reported: Restlessness

Losartan:
Frequency not reported: Anxiety, anxiety disorder, confusion, dream abnormality, depression, insomnia, libido decreased, nervousness, panic disorder, sleep disorder[Ref]

Genitourinary

Hydrochlorothiazide:
Frequency not reported: Glycosuria

Losartan:
Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection[Ref]

Immunologic

Losartan:
Postmarketing reports: Anaphylactic reactions[Ref]

References

1. "Product Information. Hyzaar (losartan-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Hyzaar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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