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Hysone Side Effects

Generic Name: clioquinol / hydrocortisone topical

Note: This page contains information about the side effects of clioquinol / hydrocortisone topical. Some of the dosage forms included on this document may not apply to the brand name Hysone.

For the Consumer

Applies to clioquinol / hydrocortisone topical: topical cream, topical ointment

In addition to its needed effects, some unwanted effects may be caused by clioquinol / hydrocortisone topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking clioquinol / hydrocortisone topical:

Incidence not known:
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • burning and itching of the skin with pinhead-sized red blisters
  • burning, itching, and pain in hairy areas, or pus at the root of the hair
  • darkening of the skin
  • diarrhea
  • dizziness
  • dryness
  • fainting
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • joint pain, stiffness, or swelling
  • loss of appetite
  • mental depression
  • nausea
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
  • vomiting

Minor Side Effects

Some of the side effects that can occur with clioquinol / hydrocortisone topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Acne or pimples
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of the treated areas of dark skin

For Healthcare Professionals

Applies to clioquinol / hydrocortisone topical: topical cream, topical kit, topical ointment


There have been a few reports of rash, hypersensitivity, and thinning of the skin following use of this combination product.[Ref]


Topical corticosteroids:
Frequency not reported: Burning, itching, irritation, dryness, folliculitis, blistering, peeling, redness, swelling, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria, irritation[Ref]


Frequency not reported: Rash, bruising, skin thinning
Postmarketing reports: Erythema, urticaria, skin pain, skin exfoliation, underlying symptoms exacerbated, hair discolored[Ref]


Postmarketing reports: Hypothalamic-pituitary adrenal (HPA) axis suppression, cushingoid features, endogenous cortisol levels decreased, steroid withdrawal syndrome[Ref]


Frequency not reported: Hypersensitivity[Ref]


Frequency not reported: Glucosuria


Frequency not reported: Bruising


Postmarketing reports: Cataract, glaucoma[Ref]


Postmarketing reports: Growth retardation/weight gain delayed in children, osteoporosis[Ref]


Postmarketing reports: Obesity/weight increased, hyperglycemia[Ref]


Postmarketing reports: Hypertension[Ref]


1. "Product Information. Dermasorb AF (clioquinol-hydrocortisone topical)." Crown Laboratories, Johnson City, TN.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Ala-Quin (clioquinol-hydrocortisone topical)." Crown Laboratories, Johnson City, TN.

Not all side effects for Hysone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Hysone (clioquinol / hydrocortisone topical)

Consumer resources

Other brands: Ala-Quin, Dermasorb AF

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.