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Hydrochlorothiazide / olmesartan Side Effects

Medically reviewed by Last updated on Dec 28, 2021.

For the Consumer

Applies to hydrochlorothiazide / olmesartan: oral tablet


Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus when used during pregnancy. Stop therapy as soon as possible if pregnancy is detected.

Side effects requiring immediate medical attention

Along with its needed effects, hydrochlorothiazide/olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / olmesartan:

Less common

  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • chest pain
  • difficult, burning, or painful urination
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • increased hunger
  • increased urination
  • joint pain, stiffness, or swelling
  • lower back, side, or stomach pain
  • rapid weight gain
  • sweating
  • swelling of the feet or lower legs
  • tingling of the hands or feet
  • troubled breathing
  • unexplained weight loss
  • unusual weight gain or loss


  • Swelling or puffiness of the face

Incidence not known

  • Convulsions
  • decrease in amount of urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • rash
  • severe diarrhea with weight loss

Side effects not requiring immediate medical attention

Some side effects of hydrochlorothiazide / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion or pain
  • fever
  • headache
  • head congestion
  • hoarseness or other voice changes
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat

Less common

  • Acid or sour stomach
  • belching
  • difficulty with moving
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • joint pain, stiffness, or swelling
  • loss of appetite
  • muscle pain or stiffness
  • pain, swelling, or redness in the joints
  • sensation of spinning
  • stomach discomfort or upset
  • weakness

Incidence not known

  • Diarrhea
  • muscle pain or stiffness
  • nervousness
  • weakness or heaviness of the legs

For Healthcare Professionals

Applies to hydrochlorothiazide / olmesartan: oral tablet


The most common side effect was dizziness.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Syncope


Common (1% to 10%): Dizziness, headache

Postmarketing reports: Lightheadedness, paresthesia


Common (1% to 10%): Dizziness, headache[Ref]


Common (1% to 10%): Bronchitis, pharyngitis, sinusitis, upper respiratory tract infection, coughing, nasopharyngitis


Common (1% to 10%): Bronchitis, nasopharyngitis, pharyngitis

Uncommon (0.1% to 1%): Sinusitis, upper respiratory tract infection, cough

Frequency not reported: Pneumonitis, pulmonary edema


Common (1% to 10%): Bronchitis, nasopharyngitis, sinusitis, upper respiratory tract infection, cough, pharyngitis, rhinitis[Ref]


Common (1% to 10%): Vertigo, Influenza-like symptoms, chest pain, fatigue, peripheral edema

Uncommon (0.1% to 1%): Weakness

Postmarketing reports: Asthenia, lethargy, malaise


Common (1% to 10%): Vertigo, influenza-like symptoms

Uncommon (0.1% to 1%): Chest pain, fatigue, peripheral edema

Frequency not reported: Weakness, fever


Common (1% to 10%): Vertigo, chest pain, fatigue, influenza-like symptoms, peripheral edema, pain

Postmarketing reports: Asthenia, lethargy, malaise[Ref]


Common (1% to 10%): Diarrhea, gastroenteritis, nausea, abdominal pain, dyspepsia

Postmarketing reports: Sprue-like enteropathy, vomiting


Uncommon (0.1% to 1%): Diarrhea, dyspepsia, nausea, gastroenteritis

Frequency not reported: Sialadenitis, cramping, gastric irritation

Postmarketing reports: Constipation


Common (1% to 10%): Diarrhea, dyspepsia, nausea, gastroenteritis, abdominal pain

Postmarketing reports: Vomiting, sprue-like enteropathy[Ref]


Common (1% to 10%): Back pain, creatine phosphokinase increased, arthralgia, arthritis, myalgia

Uncommon (0.1% to 1%): Pain in limb, spinal disorder

Postmarketing reports: Rhabdomyolysis


Common (1% to 10%): Arthralgia, back pain, pain in limb

Uncommon (0.1% to 1%): Spinal disorder

Frequency not reported: Muscle spasm


Common (1% to 10%): Arthralgia, back pain, pain in limb, arthritis, skeletal pain, creatine phosphokinase increased

Uncommon (0.1% to 1%): Spinal disorder, myalgia

Postmarketing reports: Rhabdomyolysis[Ref]


Common (1% to 10%): Hyperlipemia, hyperglycemia, blood uric acid increased, hyperuricemia

Uncommon (0.1% to 1%): Blood glucose increased, blood potassium decreased, blood potassium increased, hypertriglyceridemia

Postmarketing reports: Hyperkalemia


Common (1% to 10%): Blood glucose increased, blood potassium decreased

Uncommon (0.1% to 1%): Blood uric acid increased

Frequency not reported: Hyperglycemia, glycosuria, hyperuricemia

Postmarketing reports: Anorexia, loss of appetite


Common (1% to 10%): Hypertriglyceridemia, hyperglycemia, hyperuricemia

Uncommon (0.1% to 1%): Blood glucose increased, blood potassium decreased, blood uric acid increased

Rare (less than 0.1%): Hyperkalemia

Frequency not reported: Hypercholesterolemia[Ref]


Common (1% to 10%): GGT increased, AST increased, ALT increased


Uncommon (0.1% to 1%): ALT increased, AST increased, GGT increased

Frequency not reported: Pancreatitis, intrahepatic cholestatic jaundice


Common (1% to 10%): ALT increased, AST increased, GGT increased[Ref]


Common (1% to 10%): Hematuria, urinary tract infection


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Urinary tract infection, hematuria[Ref]


Uncommon (0.1% to 1%): Anxiety, insomnia


Uncommon (0.1% to 1%): Anxiety, insomnia

Frequency not reported: Restlessness

Postmarketing reports: Sleep disturbances, depression


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Anxiety[Ref]


Common (1% to 10%): Rash, facial edema

Uncommon (0.1% to 1%): Eczema

Postmarketing reports: Alopecia, pruritus, urticaria


Frequency not reported: Purpura, photosensitivity, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis

Postmarketing reports: Rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus, erythematosus


Uncommon (0.1% to 1%): Rash

Postmarketing reports: Alopecia, pruritus, urticaria[Ref]


Common (1% to 10%): Influenza

Uncommon (0.1% to 1%): Viral infection

Frequency not reported: Angioedema

Postmarketing reports: Anaphylactic reactions


Uncommon (0.1% to 1%): Influenza, viral infection

Frequency not reported: Anaphylactic reactions


Common (1% to 10%): Influenza

Uncommon (0.1% to 1%): Viral infection

Postmarketing reports: Angioedema, anaphylactic reactions[Ref]


Uncommon (0.1% to 1%): Blood creatinine increased

Postmarketing reports: Acute renal failure


Uncommon (0.1% to 1%): Blood creatinine increased

Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis


Uncommon (0.1% to 1%): Blood creatinine increased

Postmarketing reports: Acute renal failure[Ref]


Uncommon (0.1% to 1%): Palpitations, hypotension, orthostatic hypotension


Frequency not reported: Vasculitis, cutaneous vasculitis

Postmarketing reports: Cardiac arrhythmias, postural hypotension


Uncommon (0.1% to 1%): Tachycardia, angina pectoris

Rare (less than 0.1%): Hypotension[Ref]



Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Postmarketing reports: Bone marrow depression[Ref]


Ocular side effects have included idiosyncratic reactions to the hydrochlorothiazide component resulting in acute transient myopia and acute angle-closure glaucoma.[Ref]


1. "Product Information. Benicar HCT (hydrochlorothiazide-olmesartan)." Sankyo Pharma (2003):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.