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Hyalgan Side Effects

Generic name: sodium hyaluronate

Medically reviewed by Drugs.com. Last updated on Mar 9, 2023.

Note: This document contains side effect information about sodium hyaluronate. Some dosage forms listed on this page may not apply to the brand name Hyalgan.

Applies to sodium hyaluronate: injection gel/jelly, injection solution.

Serious side effects of Hyalgan

Along with its needed effects, sodium hyaluronate (the active ingredient contained in Hyalgan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium hyaluronate:

Less common

Other side effects of Hyalgan

Some side effects of sodium hyaluronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to sodium hyaluronate: injectable gel, intra-articular solution.

Local

Common (1% to 10%): Injection site pain/swelling/effusion/redness/warmth

Uncommon (0.1% to 1%):[Ref]

Hypersensitivity

Frequency not reported: Hayfever reaction on face and neck, reaction on forearms and knees

Postmarketing reports: Anaphylaxis/anaphylactoid reaction[Ref]

Other

Frequency not reported: Swelling of the face/eyelids/mouth/extremities, fever[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, dyspepsia[Ref]

Cardiovascular

Frequency not reported: Transient hypotension[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (18%), arthropathy/arthrosis/arthritis (11%)

Common (1% to 10%): Back pain, leg discomfort, leg pain[Ref]

Immunologic

Common (1% to 10%): Influenza-like reaction[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Respiratory

Common (1% to 10%): Upper respiratory tract infection, sinusitis, bronchitis, rhinitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]

Dermatologic

Frequency not reported: Rash, itching[Ref]

References

1. Product Information. Hyalgan (sodium hyaluronate). Sanofi Winthrop Pharmaceuticals. PROD.

2. Product Information. Supartz (sodium hyaluronate). Smith and Nephew Wound Management Division. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.