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Homatropaire Side Effects

Generic Name: homatropine ophthalmic

Note: This document contains side effect information about homatropine ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Homatropaire.

For the Consumer

Applies to homatropine ophthalmic: ophthalmic solution

Side effects include:

Elevated IOP, transient stinging, burning. With prolonged administration, local irritation (characterized by follicular conjunctivitis, vascular congestion, edema, exudate, and eczematoid dermatitis ), thirst, dry mouth, increased light sensitivity of eyes.

For Healthcare Professionals

Applies to homatropine ophthalmic: compounding powder, ophthalmic solution


Ocular side effects have included transient stinging and burning, eye irritation, and increased sensitivity to light. Prolonged use may produce local irritation characterized by follicular conjunctivitis, vascular congestion, edema, exudate and an eczematoid dermatitis.[Ref]


Gastrointestinal side effects have included thirst and dry mouth.[Ref]

Nervous system

Nervous system effects due to chronic use of the drug can lead to a confusional state characterized by delirium, agitation, and rarely coma. This state is associated with use in the pediatric and geriatric age groups.[Ref]

The specific antidote for this systemic anticholinergic syndrome is injectable physostigmine salicylate.[Ref]


1. "Product Information. Isopto Homatropine (homatropine ophthalmic)." Southwood Pharmaceuticals Inc, Irvine, CA.

Some side effects of Homatropaire may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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