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HC-Derma-Pax Side Effects

Generic Name: diphenhydramine / hydrocortisone topical

Note: This page contains information about the side effects of diphenhydramine / hydrocortisone topical. Some of the dosage forms included on this document may not apply to the brand name HC-Derma-Pax.

For the Consumer

Applies to diphenhydramine / hydrocortisone topical: spray

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; mild stinging, burning, or itching.

Seek medical attention right away if any of these SEVERE side effects occur while taking diphenhydramine / hydrocortisone topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning, cracking, irritation, or peeling not present before you began using hydrocortisone/diphenhydramine spray; excessive hair growth; inflamed hair follicles; inflammation around the mouth; thinning, softening, or discoloration of the skin.

For Healthcare Professionals

Applies to diphenhydramine / hydrocortisone topical: topical spray


Dermatologic side effects including local irritation have been reported to occur very rarely.[Ref]


1. "Product Information. HC Derma Pax (diphenhydramine-hydrocortisone topical)" Recsei Laboratories, Goleta, CA.

Not all side effects for HC-Derma-Pax may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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