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HC-Derma-Pax Side Effects

Generic name: diphenhydramine / hydrocortisone topical

Medically reviewed by Last updated on Jan 23, 2024.

Note: This document contains side effect information about diphenhydramine / hydrocortisone topical. Some dosage forms listed on this page may not apply to the brand name HC-Derma-Pax.

Applies to diphenhydramine/hydrocortisone topical: external liquid.

Serious side effects of HC-Derma-Pax

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of HC-Derma-Pax

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to diphenhydramine/hydrocortisone topical: topical spray.


Dermatologic side effects including local irritation have been reported to occur very rarely.[Ref]

More about HC-Derma-Pax (diphenhydramine / hydrocortisone topical)

Patient resources

Related treatment guides


1. "Product Information. HC-Derma-Pax (diphenhydramine-hydrocortisone topical)." Recsei Laboratories

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.