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Gynazole-1 Side Effects

Generic name: butoconazole topical

Medically reviewed by Last updated on Jul 24, 2023.

Note: This document contains side effect information about butoconazole topical. Some dosage forms listed on this page may not apply to the brand name Gynazole-1.

Applies to butoconazole topical: intravaginal cream.

Side effects include:

Vulvar/vaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping.

For Healthcare Professionals

Applies to butoconazole topical: vaginal cream.


Common (1% to 10%): Vulvar/vaginal burning, itching, soreness, swelling; pelvic pain or cramping[Ref]


Frequency not reported: Irritation[Ref]


Common (1% to 10%): Abdominal pain or cramping[Ref]

Nervous system

Frequency not reported: Headache[Ref]


Frequency not reported: Thrombocytopenia[Ref]

Thrombocytopenia developed 1 week after beginning this drug. It resolved slowly over the next few weeks after drug discontinuation.[Ref]


1. Ruf H, Vitse M. A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. J Int Med Res. 1990;18:389-99.

2. Brown D Jr, Henzl MR, LePage ME, Tsao LL, Izu AE, Walker KA, Adamson GD, Droegmuller W. Butoconazole vaginal cream in the treatment of vulvovaginal candidiasis. Comparison with miconazole nitrate and placebo. J Reprod Med. 1986;31:1045-8.

3. Butoconazole or vulvovaginal candidiasis. Med Lett Drugs Ther. 1986;28:68.

4. Product Information. Femstat (butoconazole topical). Syntex Laboratories Inc. 2022.

5. Maloley PA, Nelson E, Montgomery HA, Campbell JR. Severe reversible thrombocytopenia resulting from butoconazole cream. DICP. 1990;24:143-4.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.