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Gelsyn-3 Side Effects

Generic name: sodium hyaluronate

Medically reviewed by Last updated on Aug 4, 2023.

Note: This document contains side effect information about sodium hyaluronate. Some dosage forms listed on this page may not apply to the brand name Gelsyn-3.

Applies to sodium hyaluronate: injection gel/jelly, injection solution.

Serious side effects of Gelsyn-3

Along with its needed effects, sodium hyaluronate (the active ingredient contained in Gelsyn-3) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium hyaluronate:

Less common

Other side effects of Gelsyn-3

Some side effects of sodium hyaluronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to sodium hyaluronate: injectable gel, intra-articular solution.


Common (1% to 10%): Injection site pain/swelling/effusion/redness/warmth

Uncommon (0.1% to 1%):[Ref]


Frequency not reported: Hayfever reaction on face and neck, reaction on forearms and knees

Postmarketing reports: Anaphylaxis/anaphylactoid reaction[Ref]


Frequency not reported: Swelling of the face/eyelids/mouth/extremities, fever[Ref]


Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, dyspepsia[Ref]


Frequency not reported: Transient hypotension[Ref]


Very common (10% or more): Arthralgia (18%), arthropathy/arthrosis/arthritis (11%)

Common (1% to 10%): Back pain, leg discomfort, leg pain[Ref]


Common (1% to 10%): Influenza-like reaction[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis, bronchitis, rhinitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]


Frequency not reported: Rash, itching[Ref]


1. "Product Information. Hyalgan (sodium hyaluronate)." Sanofi Winthrop Pharmaceuticals

2. (2001) "Product Information. Supartz (sodium hyaluronate)." Smith and Nephew Wound Management Division

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.